Minimum concrete cover for rebar, rebar diameter, concrete compressive strength, embedded length of rebar, and lateral reinforcement by stirrups are the crucial factors considered in existing predicting equations and regulations for predicting rebar-concrete interface (RCI) bond strength. However, considerable effects of concrete composition on RCI are ignored in design codes and investigations. This paper intends to comprehensively highlight the critical aspects of this research gap. Additionally, a practical experimental approach is described in the present study to efficiently consider the effect of the new generations of concrete on RCI bond strength. Finally, nano-concrete is considered as a case study to show the importance of nanoparticle types on RCI bond strength. Overall results show that studying the microstructure of the transition zone at RCI is essential to accompany with the RCI bond strength for considering new generations of concrete in reinforced concrete structures. Additionally, the current study emphasizes that more investigations are necessary to be conducted by future works to fill the existing research gaps in RCI.