Investigating the effect of nonionic surfactant on the silica nanoparticles formation and morphology in a microfluidic reactor

Microfluidic Chips for Formulation of Silica Nanoparticles and Enzyme Immobilization

“…The experiment was conducted in an open-loop microfluidic flow system at room temperature using the experimental setup as reported in previous studies [53,54]. The vacuum and pressure controller (Elveflow OB1 MK3) controlled both inlet flow rates by setting the operating pressure using the Elvelfow Smart Interface software.…”

“…Exact amounts of R. miehei lipase and silica NPs were added separately into 20 mL of 25 mM sodium phosphate buffer solution and placed in two different centrifuge tubes. Both solutions were allowed to flow into the microreactor at different operating pressures varying from 70 to 150 mbar to give various residence times using the same experimental setup reported previously [53,54]. The solution that flowed out from the microreactor was collected and centrifuged at 13 000 rpm for 1 min to separate the lipase solution and the solid.…”

Heterogeneous Microfluidic Reactors: A Review and an Insight of Enzymatic Reactions

“…Chiptype microreactors show many advantages, such as easy control of microfluidics and integrating many processes into one reaction device [31]. Ling et al [40,41] fabricated a PDMS microreactor consisting of a T-junction as a droplet generator to synthesize silica nanoparticles. The microreactor successfully produced highly monodispersed silica nanoparticles adapting the known sol-gel method, with perfect spherical configuration and narrower particle size distribution compared with the bench-scale method.…”