This study aims to reveal the effectiveness of the authentic research project-based laboratory work to develop creative thinking skills, scientific attitudes, and students' scientific work skills in high school biology learning. The 34 students of class X MIPA from one of the public high schools in Mataram, West Nusa Tenggara Indonesia, carried out authentic research project-based laboratory work and 34 other students with verification laboratory work. Creative thinking skills were assessed using a creative thinking skills test compiled by researchers. Tests were administered before and after the intervention. Scientific attitude is assessed using the observation method, and scientific workability is assessed using self and peer assessment instruments. The results showed that the authentic research project-based laboratory work encourages creative thinking skills, stimulates scientific attitudes and students' scientific work abilities. This study concludes that the authentic research project-based laboratory work provides insight into how the authentic research project-based laboratory work encourages creative thinking, shows benefits in instilling scientific attitudes, improves students' scientific workability, and the limitations of the approach in this study.