Investigating the effect of tamsulosin on the measurement of bladder wall thickness and International Prostate Symptom Score in benign prostatic hyperplasia

Eghbali, Kamyar; Shayegan, Mohammad Reza; Kianoush, Sina

doi:10.5489/cuaj.11262

Cited by 7 publications

(12 citation statements)

References 25 publications

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“…BWT has been shown to improve with alpha‐blocker therapy, and negatively correlate with the responsiveness of alpha‐blockers. Similar to BWT, DWT has been found to correlate with BOOI and decrease in DWT after transurethral prostatectomy …”

Section: Discussionmentioning

confidence: 88%

Establishment and value assessment of efficacy prediction model about transurethral prostatectomy

Huang

et al. 2015

Int J of Urology

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Abbreviations & Acronyms AUC = area under the curve AUR = acute urinary retention BCI = bladder contractility index BOO = bladder outlet obstruction BOOI = bladder outlet obstruction index BWT = bladder wall thickness DO = detrusor overactivity DWT = detrusor wall thickness IPP = intravesical prostatic protrusion IPSS = International Prostate Symptom Score IPSS -s = storage score IPSS -v = voiding score LUTS/BPO = lower urinary tract symptoms suggestive of benign prostatic obstruction MODS = multiple organ dysfunction symptom m P ura = maximum pressure of urethra NPV = negative predictive value P det Q max = pressure of detrusor at maximum flow rate PPV = positive predictive value PSA = prostate-specific antigen PVR = post-voiding residue Q max = maximum flow rate QoL = quality of life RI = resistive index ROC = receiver operating characteristic R res = weight ratio of resection R s/v = ratio of IPSS -s and IPSS -v TPV = total prostate volume T res = time of resection TURP = transurethral prostatectomy TURS = TUR syndrome TZV = transitional zone volume UDS = urodynamics UEBW = ultrasonic estimation of bladder weight US = ultrasonography UTI = urinary tract infection UUI = urge urinary incontinence W res = tissue weight of resection Objectives: To establish and to evaluate discriminant models to predict the outcomes of transurethral prostatectomy. Methods: Clinical data of patients treated with transurethral prostatectomy between January and December 2013 were collected, including medical history, symptoms, biochemical tests, ultrasonography and urodynamics. Surgical efficacy was evaluated at 6-month follow up. Predictive models were constructed by logistic regression. Receiver operating characteristic curve and diagnostic tests were used to test the accuracy of models before the predictive value between models was compared. Results: A total of 182 patients were included, with 73.6% having an effective outcome. History of recurrent urinary tract infection (OR 1.33), score of storage phase (OR 2.58), maximum flow rate (OR 2.11) and detrusor overactivity (OR 3.13) were found to be risk factors. International Prostate Symptom Score (OR 0.13), transitional zone index (OR 0.58), resistive index of prostatic artery (OR 0.46), bladder wall thickness (OR 0.78), ultrasonic estimation of bladder weight (OR 0.28), bladder outlet obstruction index (OR 0.20) and bladder contractility index (OR 0.83) were found to be protective factors. The areas under the curve of models using factors from ultrasonography and urodynamics were 0.792 and 0.829 respectively, with no significant difference being found between them (P = 0.348). Conclusions: Surgical efficacy of transurethral prostatectomy is positively correlated to severe voiding phase symptoms, outlet obstruction and better detrusor contractility, and negative correlated with urinary infection, severe storage phase symptoms and excessive detrusor contractibility. Ultrasonography might replace urodynamics in selecting patients for whom transurethral prostatectomy is more likely t...

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Section: Discussionmentioning

confidence: 88%

Establishment and value assessment of efficacy prediction model about transurethral prostatectomy

Huang

et al. 2015

Int J of Urology

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“…In the first stage of study, all patients from treatment group (313 persons) were taking Tamsulosin 0.4 mg within 8 weeks [26,27]. Patients from control group (114 persons) were taking placebo.…”

Section: Working Hypothesismentioning

confidence: 99%

Additional correction of OAB symptoms by two anti-muscarinics for men over 50 years old with residual symptoms of moderate prostatic obstruction after treatment with Tamsulosin

et al. 2014

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“…Several studies have evaluated the effects of pharmacologic treatment for BPO on BWT. Treatment with α‐blockers has been shown to significantly reduce BWT in various studies . De Nunzio et al evaluated the effect of dutasteride add‐on therapy in patients with 27 “BPH” already being treated with α‐blockers .…”

Section: When and Under Which Circumstances Is The Recovery Of The Blmentioning

confidence: 99%

“…Treatment with α-blockers has been shown to significantly reduce BWT in various studies. [37][38][39] De Nunzio et al 40 evaluated the effect of dutasteride add-on therapy in patients with 27 "BPH" already being treated with α-blockers. 40 After 24 weeks of treatment, they observed a significant reduction in DWT.…”

Section: Circumstances Is the Recovery Of The Bladder Possible After mentioning

confidence: 99%

Do functional changes occur in the bladder due to bladder outlet obstruction? ‐ ICI‐RS 2018

Bosch

Abrams

Averbeck

et al. 2019

Neurourology and Urodynamics

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Studies on bladder dysfunction (BD), more specifically functional‐urodynamic changes in the bladder as a result of bladder outlet obstruction (BOO) have been summarized for this TT. Based on available, but limited evidence from human studies a three‐stage model can be hypothesized to characterize BOO‐induced bladder remodeling: hypertrophy, compensation (increased detrusor contractility during the voiding phase, often in combination with filling phase detrusor overactivity) followed by the phase of decompensation [detrusor underactivity]. The time between the start of compensation and eventual decompensation seems to be determined by age of onset, severity, and type of obstruction and clinical mitigating factors such as vascular and metabolic problems. Understanding the relative contributions of these factors may allow the development of personalized timelines and probabilities for these obstructed patients.

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Investigating the effect of tamsulosin on the measurement of bladder wall thickness and International Prostate Symptom Score in benign prostatic hyperplasia

Cited by 7 publications

References 25 publications

Establishment and value assessment of efficacy prediction model about transurethral prostatectomy

Establishment and value assessment of efficacy prediction model about transurethral prostatectomy

Additional correction of OAB symptoms by two anti-muscarinics for men over 50 years old with residual symptoms of moderate prostatic obstruction after treatment with Tamsulosin

Do functional changes occur in the bladder due to bladder outlet obstruction? ‐ ICI‐RS 2018

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