Investigating the Effects of Atrial Natriuretic Peptide on the Maternal Endothelium to Determine Potential Implications for Preeclampsia

Binder, Natalie; Beard, Sally; Alwis, Natasha de; Fato, Bianca R.; Nguyen, Thu Annelise; Kaitu’u-Lino, Tu’uhevaha J; Hannan, Natalie J.

doi:10.3390/ijms24076182

Cited by 3 publications

(2 citation statements)

References 61 publications

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“…The conditioned medium from the ANP-treated endometrial stromal cells also had an increased activity in inducing apoptosis in uterine smooth muscle cells [15]. On the other hand, ANP treatment in cultured human endothelial cells did not alter cell proliferation and migration or prevent TNFα-induced dysfunction [127]. These findings are consistent, indicating an important role for ANP in inducing TRAIL expression and release from endometrial stromal cells, causing apoptosis in arterial smooth muscle cells [15].…”

Section: Role Of Anp In Decidual and Vascular Cell Interactions 621 D...mentioning

confidence: 61%

Natriuretic Peptide Signaling in Uterine Biology and Preeclampsia

2023

IJMS

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Endometrial decidualization is a uterine process essential for spiral artery remodeling, embryo implantation, and trophoblast invasion. Defects in endometrial decidualization and spiral artery remodeling are important contributing factors in preeclampsia, a major disorder in pregnancy. Atrial natriuretic peptide (ANP) is a cardiac hormone that regulates blood volume and pressure. ANP is also generated in non-cardiac tissues, such as the uterus and placenta. In recent human genome-wide association studies, multiple loci with genes involved in natriuretic peptide signaling are associated with gestational hypertension and preeclampsia. In cellular experiments and mouse models, uterine ANP has been shown to stimulate endometrial decidualization, increase TNF-related apoptosis-inducing ligand expression and secretion, and enhance apoptosis in arterial smooth muscle cells and endothelial cells. In placental trophoblasts, ANP stimulates adenosine 5′-monophosphate-activated protein kinase and the mammalian target of rapamycin complex 1 signaling, leading to autophagy inhibition and protein kinase N3 upregulation, thereby increasing trophoblast invasiveness. ANP deficiency impairs endometrial decidualization and spiral artery remodeling, causing a preeclampsia-like phenotype in mice. These findings indicate the importance of natriuretic peptide signaling in pregnancy. This review discusses the role of ANP in uterine biology and potential implications of impaired ANP signaling in preeclampsia.

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Section: Role Of Anp In Decidual and Vascular Cell Interactions 621 D...mentioning

confidence: 61%

Natriuretic Peptide Signaling in Uterine Biology and Preeclampsia

2023

IJMS

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“…Little is known regarding the role of atrial natriuretic peptide (ANP) and endothelial development in preeclampsia. Few studies have investigated this field so far ( 20 ). While our institution currently does not evaluate routine ANP levels during pregnancy, further studies should also investigate its role in the development of preeclampsia.…”

Section: Limitationsmentioning

confidence: 99%

Natriuretic peptide biomarkers in the imminent development of preeclampsia

Marek-Iannucci¹,

Oliveros²,

Brailovsky³

et al. 2023

Front. Cardiovasc. Med.

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Preeclampsia is the most common cause of morbidity and mortality in pregnancy, the incidence being significantly higher in low-income countries with reduced access to health care. Women with preeclampsia are at a higher risk of developing cardiovascular disease with a poorer long-term outcome. Early recognition and treatment are key to improving short- and long-term outcomes. Approximately 3%–5% of pregnant women will develop preeclampsia, with potentially fatal outcomes. Despite ongoing research, the exact pathophysiologic mechanism behind its development remains unclear. In this brief report, we describe the potential role of natriuretic peptides as biomarkers in the imminent development of preeclampsia. In a retrospective manner, we analyzed changes in the left ventricular ejection fraction and left atrial volume and increases in natriuretic peptide in correlation with the development of preeclampsia. We found that three out of four patients developed a significant increase in natriuretic peptide, which correlated with the development of preeclampsia and/or peripartum cardiomyopathy. Significant increases in natriuretic peptides around the time of delivery might be a marker for the imminent development of preeclampsia. Close monitoring of natriuretic peptide levels in the peripartum period could give important insight into the imminent development of preeclampsia in high-risk patients. Close follow-up in specialized cardio-obstetric clinics is highly recommended.

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Comparative study of the three-dimensional genomes of granulosa cells in germinal vesicle and metaphase II follicles

Mao,

Cai,

Wang

et al. 2024

Front. Genet.

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IntroductionFollicle development is a critical process in the female reproductive system, with significant implications for fertility and reproductive health. Germinal vesicle (GV) oocytes are primary oocytes that are arrested in the dictyate stage, also known as the diplotene stage of meiotic prophase I. Metaphase II (MII) is the stage at which the oocyte is typically retrieved for assisted reproductive technologies such as in vitro fertilization (IVF). The granulosa cells play a pivotal role in follicle development processes. 3D chromatin organization is a fundamental aspect of cellular biology that has significant implications for gene regulation and cellular function.MethodsIn this study, we investigated 3D chromatin organization in granulosacells from GV and MII follicles, which is essential for understanding the regulatory mechanisms governing oocyte development.ResultsThe results revealed distinct compartmentalization patterns,including stable genomic regions and transitions during oocyte maturation. Notably, there was a significant shift in functional gene activation, particularly in processes related to hormone metabolic pathways. Furthermore, alterations in topologically associating domains (TADs) were observed, with differential expression observed in genes that are involved in crucial biological processes. The analysis also identified a subset of genes with altered promoter-enhancer interactions (PEIs), reflecting a regulatory shift in gene expression related to reproductive processes.DiscussionThese findings provide valuable insights into 3D genome organization in granulosa cells with implications for reproductive health and the development of assisted reproductive technologies. Understanding spatial genome organization at different stages of follicular development may help realize novel strategies for enhancing success rates in assisted reproductive technologies.

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Investigating the Effects of Atrial Natriuretic Peptide on the Maternal Endothelium to Determine Potential Implications for Preeclampsia

Cited by 3 publications

References 61 publications

Natriuretic Peptide Signaling in Uterine Biology and Preeclampsia

Natriuretic Peptide Signaling in Uterine Biology and Preeclampsia

Natriuretic peptide biomarkers in the imminent development of preeclampsia

Comparative study of the three-dimensional genomes of granulosa cells in germinal vesicle and metaphase II follicles

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