Investigating the effects of functionalized carbon nanotubes on reproduction and development in Drosophila melanogaster and CD-1 mice

Philbrook, Nicola A.; Walker, Virginia K.; Afrooz, A. R. M. Nabiul; Saleh, Navid B.; Winn, Louise M.

doi:10.1016/j.reprotox.2011.09.002

Cited by 86 publications

(67 citation statements)

References 37 publications

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“…An improvement in body weight gain could also be obtained with supplementation of 2500 mg/kg SiO 2 to diet of fattening chickens (Vanschoubroek and Vermeersch 1996). Although in the present study we did not measure nSiO 2 agglomeration, however, it is reported that high levels of nanoparticles in the diet, increase the possibility of their agglomeration in the small intestine leading to reduced absorption of the nanoparticles into the body (Philbrook et al 2011;Bergin and Witzmann 2013). SakaiKato et al (2014) reported that following a reduction in the electrostatic repulsion between negatively charged silica particles, agglomeration can occur in the stomach due to its lower pH conditions and as a result of agglomeration, intestinal absorption of the particles reduced.…”

Section: Discussionmentioning

confidence: 66%

Effect of nanosilicon dioxide on growth performance, egg quality, liver histopathology and concentration of calcium, phosphorus and silicon in egg, liver and bone in laying quails

Faryadi

Sheikhahmadi

2017

Appl Nanosci

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This experiment was conducted to evaluate the effects of different levels of nanosilicon dioxide (nSiO 2 ) on performance, egg quality, liver histopathology and concentration of calcium (Ca), phosphorus and silicon (Si) in egg, liver and bone in laying quails. The experiment was administered using 60 laying quails at 16-26 weeks of age with five treatments [0 (control), 500, 1000, 2000 and 4000 mg nSiO 2 per kg of diet] and four replicates in a completely randomized design. During the experiment, the amount of feed intake was recorded weekly and performance parameters were measured. During the last 3 days of the experiment, all of the eggs in each replicate were collected and egg quality parameters were measured. At the end of 26 weeks of age, the birds were sacrificed and blood samples were collected. Liver samples from each treatment were fixed in 10% buffered formalin for histopathological assessment. The right thigh bone and a portion of liver were inserted in plastic bags and stored at -20. The results showed that nSiO 2 supplementation significantly affected egg weight and egg mass (P \ 0.05). Also, dietary nSiO 2 supplementation decreased the yolk weight and increased the shell weight (P \ 0.05). Moreover, nSiO 2 increased bone ash content, Ca and Si concentration in the bone (P \ 0.05). The liver enzymes in plasma and the liver tissue histopathology were not significantly affected (P [ 0.05) by dietary treatments. In conclusion, the results indicated that dietary supplementation of nSiO 2 could improve bone density and performance without any adverse effect on the health of laying quails.

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Section: Discussionmentioning

confidence: 66%

Effect of nanosilicon dioxide on growth performance, egg quality, liver histopathology and concentration of calcium, phosphorus and silicon in egg, liver and bone in laying quails

Faryadi

Sheikhahmadi

2017

Appl Nanosci

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“…30 Further, carbon nanotubes functionalized with a hydroxyl group were reported to not affect the eclosion rate of flies. 24 Assuming a food intake of 1.5 μL per day, 38 we speculate that the maximum amount of CNFs consumed by individual flies was 0.15 or 1.5 μg/fly/day in this study, not considering reduction of feeding rate ( Figure 3B). Although the amount of CNFs in our fly diet was higher than naturally occurring levels, it is plausible for humans to ingest such abundant amounts of nanomaterials since continuous ingestion of contaminated foods or water is the most common route of nanomaterial ingestion.…”

Section: Discussionmentioning

confidence: 73%

“…Functionalized single-walled carbon nanotubes with a hydroxyl group, organically modified silica nanoparticles, and gallium phosphide nanowires have all been reported as having no significant adverse effects on Drosophila development or adult lifespan. [24][25][26] In addition, gellan gum-polyethylenimine nanocomposites show no significant effects on Drosophila survival, 27 and long-term exposure to insulin-small lipid nanoparticles developed for insulin delivery is reported to be nontoxic. 28 In the current study, we evaluated the physiological effects of long-term exposure to CNFs using D. melanogaster.…”

Section: Introductionmentioning

confidence: 99%

Effects of carbon nanofiber on physiology of Drosophila

Lee

et al. 2015

IJN

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As nanomaterials are now widely utilized in a wide range of fields for both medical and industrial applications, concerns over their potential toxicity to human health and the environment have increased. To evaluate the toxicity of long-term exposure to carbon nanofibers (CNFs) in an in vivo system, we selected Drosophila melanogaster as a model organism. Oral administration of CNFs at a concentration of 1,000 μg/mL had adverse effects on fly physiology. Long-term administration of a high dose of CNFs (1,000 μg/mL) reduced larval viability based on the pupa:egg ratio, adult fly lifespan, reproductive activity, climbing activity, and survival rate in response to starvation stress. However, CNFs at a low concentration (100 μg/mL) did not show any significant deleterious effect on developmental rate or fecundity. Furthermore, long-term administration of a low dose of CNFs (100 μg/mL) increased lifespan and climbing ability, coincident with mild reactive oxygen species generation and stimulation of the antioxidant system. Taken together, our data suggest that a high dose of CNFs has obvious physiological toxicity, whereas low-dose chronic exposure to CNFs can actually have beneficial effects via stimulation of the antioxidant defense system.

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“…62,63 SwCNTs and aquatic embryo Cheng et al 27 explored the impact of raw SWCNTs on the embryo of aquatic organisms using zebrafish embryos. They reported that SWCNTs induce a significant hatching delay in the zebrafish embryos between 52 and 72 hours postfertilization (hpf) at concentrations greater than 120 mg/L.…”

Section: Swcnts and Drosophila Embryomentioning

confidence: 99%

“…The data of this investigation clearly suggest that SWCNTs could act as embryotoxic agents in mammals. 65 Meanwhile, Philbrook et al 63 demonstrated that oral administration of SWCNTs (10 mg/kg) to pregnant CD-1 mice during organogenesis leads to increased resorptions, external morphological defects, and skeletal abnormalities.…”

Section: Swcnts and Mammalian Embryomentioning

confidence: 99%

Impact of single-walled carbon nanotubes on the embryo: a brief review

Moustafa¹,

Mfoumou²,

Roman³

et al. 2016

IJN

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Carbon nanotubes (CNTs) are considered one of the most interesting materials in the 21st century due to their unique physiochemical characteristics and applicability to various industrial products and medical applications. However, in the last few years, questions have been raised regarding the potential toxicity of CNTs to humans and the environment; it is believed that the physiochemical characteristics of these materials are key determinants of CNT interaction with living cells and hence determine their toxicity in humans and other organisms as well as their embryos. Thus, several recent studies, including ours, pointed out that CNTs have cytotoxic effects on human and animal cells, which occur via the alteration of key regulator genes of cell proliferation, apoptosis, survival, cell–cell adhesion, and angiogenesis. Meanwhile, few investigations revealed that CNTs could also be harmful to the normal development of the embryo. In this review, we will discuss the toxic role of single-walled CNTs in the embryo, which was recently explored by several groups including ours.

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Investigating the effects of functionalized carbon nanotubes on reproduction and development in Drosophila melanogaster and CD-1 mice

Cited by 86 publications

References 37 publications

Effect of nanosilicon dioxide on growth performance, egg quality, liver histopathology and concentration of calcium, phosphorus and silicon in egg, liver and bone in laying quails

Effect of nanosilicon dioxide on growth performance, egg quality, liver histopathology and concentration of calcium, phosphorus and silicon in egg, liver and bone in laying quails

Effects of carbon nanofiber on physiology of Drosophila

Impact of single-walled carbon nanotubes on the embryo: a brief review

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