Investigating the epidemiological relationship between vitiligo and psoriasis: a population-based study

Kridin, Khalaf; Lyakhovitsky, Keren; Onn, Erez; Lyakhovitsky, Anna; Ludwig, Ralf J.; Weinstein, Orly; Cohen, Arnon D.

doi:10.1007/s00403-022-02358-8

Cited by 7 publications

(4 citation statements)

References 33 publications

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“…The patients observed in this study exhibited vitiligo onset at the age of 2 and psoriasis onset at the age of 27. Similar clinical observations in Korea and Israel indicate that psoriasis is more likely to develop following the onset of vitiligo 11,12 . These findings imply that the presence of vitiligo creates a favorable environment for the subsequent development of psoriasis.…”

Section: Discussionsupporting

confidence: 59%

The relationship between psoriasis and vitiligo: From a comprehensive study

Li,

Shen,

Wang

et al. 2024

Skin Research and Technology

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BackgroundBoth psoriasis and vitiligo are autoimmune skin diseases. Previous observational studies have indicated a relationship between the two conditions, and simultaneous onset of both diseases poses increased health risks to patients. However, limited research has explored the causal relationship between psoriasis and vitiligo.ObjectivesTo investigate whether a causal association exists between psoriasis and vitiligo.MethodsA case of Chinese patients diagnosed with psoriasis and vitiligo has been reported. Transcriptome sequencing was performed on normal, psoriasis, vitiligo, and co‐morbid skin tissues of the patients, and single‐cell transcriptome sequencing was conducted on the co‐morbid skin tissues. A comprehensive Mendelian randomization analysis of Genome‐wide association studies (GWAS) was performed on a cohort of 261 018 European individuals with psoriasis from the IEU Open GWAS Project and vitiligo from the National Institutes of Health (NIH) Database of Genotypes and Phenotypes.ResultsCase report and transcriptome results showed that skin tissue with vitiligo combined with psoriasis exhibited both vitiligo and psoriasis. Single‐cell transcriptome sequencing results showed that in comparison to normal skin and psoriatic skin, the proportions of CD8+ T cells, natural killer cells, naive T cells, T helper cells 17, regulatory T cells, conventional type 1 dendritic cells, Conventional type 2 dendritic cells, and plasmacytoid dendritic cells were all increased in skin tissue with vitiligo combined with psoriasis. Mendelian randomization analysis included 4510 patients with psoriasis and 4680 patients with vitiligo. The results showed no causal relationship between vitiligo and psoriasis in the forward direction (p = 0.192; odds ratio [OR], 1.059; 95% confidence interval [CI], 0.971–1.155) or in the reverse direction (p = 0.459; OR, 0.927; 95% CI, 0.757–1.134).ConclusionsThis study suggests that the association between psoriasis and vitiligo may be closely related to immunity, however, Mendelian randomization studies do not support a causal relationship. These findings hold significant implications for clinicians aiming to enhance their understanding and treatment approaches for psoriasis and vitiligo.

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Section: Discussionsupporting

confidence: 59%

The relationship between psoriasis and vitiligo: From a comprehensive study

Li,

Shen,

Wang

et al. 2024

Skin Research and Technology

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“…Также описаны случаи носительства больным с псориазом микродупликации гена NSD1 и рецессивного изменения гена IL36RN, коррелирующего с тяжестью псориаза [8], а также сочетания синдрома Сотоса и витилиго [6]. Кроме того, для пациентов с витилиго характерен высокий риск развития псориаза [9], но не наоборот [9,10]. В этой связи можно предположить наличие общих механизмов патогенеза синдрома Сотоса, псориа-за и витилиго.…”

Section: Discussionunclassified

Combination of Psoriasis and Vitiligo in a Child with Sotos Syndrome: Clinical Case

Efanova,

Taskaeva

2024

Vopr. sovr. pediatr.

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Background. Psoriasis and vitiligo are chronic, relatively common dermatological diseases. Meanwhile, their combination in children is rare. The combination of psoriasis and vitiligo in a child with Sotos syndrome has not been previously described. Clinical case description. The boy, 10 years old, was hospitalized with complaints (according to his mother) of rashes on the scalp, body, and limbs, with mild itching that was not related to the time of day. The pathological skin process was widespread. The patient was hyperactive, restless, emotionally labile, irritable. Complaints of rashes was mentioned firstly at the age of 7. Sotos syndrome was established at the age of 8 (variant c.6559C>T (p.Arg2187Ter) in 23 exon of the NSD1 gene (5q35.3), autosomal dominant type of inheritance (pathological allele de novo)). Psoriasis vulgaris was diagnosed with secondary vitiligo (localized form) at the age of 8.5 years. Symptomatic antipruritic and external pathogenetic therapy was performed in the hospital. Phototherapy was not prescribed due to the relative contradiction (small retrocerebral cyst) and the peculiarities of major disease (hyperactivity, restlessness) that complicated to place the child in the phototherapy booth. Positive dynamics was noted during the treatment (14 days): no itching, decrease of peeling severity, flattening and blanching of psoriatic rash elements to spots of post-inflammatory hypopigmentation. The lesion (focus of depigmentation) on the right knee joint skin remained unchanged. The patient was discharged to outpatient care. The prognosis for Sotos syndrome and skin lesions is favorable. Conclusion. The first medical observation of the child with Sotos syndrome burdened with psoriasis and vitiligo is presented. The pathogenetic correlation of these diseases is not clearly defined. Management of such cases requires the joint collaboration of dermatologists, geneticists and pediatricians.

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“…Patients with psoriasis have been reported to suffer from a higher frequency of autoimmune diseases (#6), such as uveitis [ 60 ], inflammatory bowel disease [ 61 ], multiple sclerosis [ 62 ], Hashimoto’s thyroiditis [ 63 ], bullous pemphigoid [ 64 ], vitiligo [ 65 ], and alopecia areata [ 66 ]. The association between them is exerted through intricate immunopathological pathways and mechanisms, which have not yet been fully elucidated [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

Knowledge Mapping and Research Hotspots of Comorbidities in Psoriasis: A Bibliometric Analysis from 2004 to 2022

Huang

Bai

2023

Medicina

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Background and Objectives: Psoriasis is a chronic inflammatory disease whose impact on health is not only limited to the skin, but is also associated with multiple comorbidities. Early screening for comorbidities along with appropriate treatment plans can provide a positive prognosis for patients. This study aimed to summarize the knowledge structure in the field of psoriasis comorbidities and further explore its research hotspots and trends through bibliometrics. Materials and Methods: A search was conducted in the core collection of the Web of Science for literature on comorbidities of psoriasis from 2004 to 2022. VOSviewer and CiteSpace software were used for collaborative network analysis, co-citation analysis of references, and keyword co-occurrence analysis on these publications. Results: A total of 1803 papers written by 6741 authors from 81 countries was included. The publications have shown a progressive increase since 2004. The United States and Europe were at the forefront of this field. The most prolific institution was the University of California, and the most productive author was A. Armstrong. Research has focused on “psoriatic arthritis”, “metabolic syndrome”, “cardiovascular disease”, “psychosomatic disease”, “inflammatory bowel disease”, “prevalence”, “quality of life”, and “risk factor” in the past 18 years. Keywords such as “biologics” and “systemic inflammation”, have been widely used recently, suggesting current research hotspots and trends. Conclusions: Over the past 18 years, tremendous progress has been made in research on psoriasis comorbidity. However, collaborations among countries, institutions, and investigators are inadequate, and the study of the mechanisms of interaction between psoriasis and comorbidities and management of comorbidities is insufficient. The treatment of comorbidities with biologic agents, screening of comorbidities, and multidisciplinary co-management are predicted to be the focus of future research.

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Investigating the epidemiological relationship between vitiligo and psoriasis: a population-based study

Cited by 7 publications

References 33 publications

The relationship between psoriasis and vitiligo: From a comprehensive study

The relationship between psoriasis and vitiligo: From a comprehensive study

Combination of Psoriasis and Vitiligo in a Child with Sotos Syndrome: Clinical Case

Knowledge Mapping and Research Hotspots of Comorbidities in Psoriasis: A Bibliometric Analysis from 2004 to 2022

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