Investigating the Formation and Growth of α-Particle Radiation-Induced Foci of Altered Hepatocytes: A Model-Based Approach

Beyond Two-Stage Models for Lung Carcinogenesis in the Mayak Workers: Implications for Plutonium Risk

“…However, it has long been criticized [33] that no radiobiological evidence exists for such a premalignantgrowth-enhancing effect. Although experimental evidence is still sparse [50,51], let us briefly discuss some theoretical models put forward to explain how radiation might lead to enhanced proliferation of premalignant cells. Table II: Observed numbers of lung-cancer cases by dose categories, compared with those predicted by the descriptive and multi-stage models (in brackets: excess cases).…”

“…However, it has long been criticized [33] that no radiobiological evidence exists for such a premalignantgrowth-enhancing effect. Although experimental evidence is still sparse [50,51], let us briefly discuss some theoretical models put forward to explain how radiation might lead to enhanced proliferation of premalignant cells.…”

Hepatic and Perihepatic Involvement in Pneumokonioses and Other Mineral-Induced Diseases

“…Target cells susceptible to malignant transformation may undergo one event and may then migrate outside of the range of alpha particles, thereby avoiding immediate induction of successive additional events that would lead to cell death or neoplastic change (Yamamoto et al 2009). In the liver, Th (232) induces foci of altered hepatocytes that may represent early lesions in a carcinogenic pathway (Kopp-Schneider et al 2006).…”