Investigating the hemostatic effect of medicinal plant Arnebia euchroma (Royle) I.M.Johnst extract in a mouse model

Ablat, Nuramatjan; Ablimit, Mihray; Abudoukadier, Abudoureheman; Kadeer, Buhaiqiemu; Yang, Lei

doi:10.1016/j.jep.2021.114306

Cited by 8 publications

(3 citation statements)

References 39 publications

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Section: Resultsmentioning

confidence: 99%

“…Meanwhile, it may regulate platelets receptor and adenosine triphosphate enzyme by influencing the content of adenosine diphosphate and cyclic adenosine phosphate, thus inducing platelets' aggregation. [41] Moreover, histamine and taurine also played the pivotal roles in hemostasis process. Among them, histamine can induce the expression of tissue factors through the activation of protein kinase C dependent protein kinase D and histamine receptor 1.…”

Section: Plasma Metabolomics Revealing the Hemostatic Mechanism Of Cp...mentioning

confidence: 99%

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Carbonized Platycladus orientalis Derived Carbon Dots Accelerate Hemostasis through Activation of Platelets and Coagulation Pathways

Liang,

Bi,

Zhou

et al. 2023

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Achieving rapid and effective hemostasis remains a multidisciplinary challenge. Here, distinctive functional carbon dots derived from carbonized Platycladus orientalis (CPO‐CDs) are developed using one‐step hydrothermal method. The negatively charged surface of CPO‐CDs retains partial functional groups from CPO precursor, exhibiting excellent water solubility and high biocompatibility. Both rat liver injury model and tail amputation model have confirmed the rapid and effective hemostatic performance of CPO‐CDs on exogenous hemorrhage. Further, on endogenous blood‐heat hemorrhage syndrome rat model, CPO‐CDs could inhibit hemorrhage and alleviate inflammation response. Interestingly, the excellent hemostasis performance of CPO‐CDs is ascribed to activate exogenous coagulation pathway and common coagulation pathway. More importantly, metabolomics of rat plasma suggests that the hemostasis effect of CPO‐CDs is closely related to platelet functions. Therefore, the designed in vitro experiments are performed and it is discovered that CPO‐CDs significantly promote platelets adhesion, activation, and aggregation. Further, the underlying mechanism investigation suggests that Src/Syk signal pathway plays a key role in platelets activation triggered by CPO‐CDs. Overall, CPO‐CDs with rapid and excellent hemostatic performance are discovered for the first time, which could be an excellent candidate for the treatment of hemorrhagic diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Plasma Metabolomics Revealing the Hemostatic Mechanism Of Cp...mentioning

confidence: 99%

Carbonized Platycladus orientalis Derived Carbon Dots Accelerate Hemostasis through Activation of Platelets and Coagulation Pathways

Liang,

Bi,

Zhou

et al. 2023

Small

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“…Plant-derived compounds and extracts are promising sources of hemostatic agents, offering low toxicity and minimal adverse reactions in the human body [ 21 , 22 , 23 , 24 ]. Among these, natural ingredients like aloe vera and lotus root stand out for their potential to influence hemostasis [ 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Rational Design and Testing of Antibacterial Aloe Vera Hemostatic Hydrogel

Shin,

Hillyer,

Shin

2024

Gels

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Bleeding resulting from surgical procedures or trauma, including gunshot wounds, represents a life-threatening health issue. Therefore, the development of safe, effective, and convenient hemostatic agents is critical in securing the “golden time” to save patients’ lives. Plant-derived compounds and plant extracts have been regarded as promising sources of hemostatic agents in previous studies, regulating hemostatic function with low toxicity and minimal side effects within the human body. Aloe vera-based hydrogels, which are characterized by flexible strength and high functionality, have emerged as a promising platform for wound applications due to their unique biocompatibility features. This study provides a comprehensive exploration of the utilization of thickening agents and natural agents such as xanthan gum, carrageenan, Carbomer, and alginate in applying aloe vera-based hydrogels as a hemostatic. Furthermore, it also tests the use of aloe vera-based hydrogels for therapeutic delivery at wound sites through the incorporation of various antimicrobial agents to extend the utility of the hydrogels beyond hemostasis. Our novel applied research utilizes aloe vera-based hydrogel as an antimicrobial hemostatic agent, providing valuable insights for a wide range of applications and highlighting its potential to enhance hemorrhage control in various emergency scenarios.

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Potential novel role of the human amniotic membrane as a sustainable hemostat

Mousa,

Soliman,

Al‐Mofty

2024

Intl J Gynecology & Obste

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ObjectivesAcute hemorrhage can cause significant morbidity and mortality arising from trauma, bleeding disorders, surgical procedures, or obstetric complications. Surgical hemostasis methods may fail to stop acute bleeding due to the complex bleeding dynamics of each bleeding type. Therefore, developing safe and effective topical hemostatic agents remains crucial. The human amniotic membrane (hAM) has established clinical evidence of effectiveness in promoting wound healing and tissue regeneration. Despite its unique biological and immunologic properties and its structural composition of established hemostatic elements, the hemostatic role of hAM has not been yet explored. The present study aimed to investigate this potential role and to describe the development protocol and characterization of hAM‐derived topical hemostat.MethodsSurface electron microscope (SEM) imaging and Fourier transform infrared (FTIR) spectroscopy were used for characterization, and mouse models with induced peritoneal and tail wound bleeding were employed to evaluate the hemostatic effectiveness using physiological studies, in comparison to a chitosan‐based combat‐scale hemostat.ResultsThe hAM hemostat showed a distinctive composition by SEM and FTIR. Applying equal masses of the hAM hemostat, the commercial hemostat, or a combination reduced peritoneal wound bleeding time to averages of 108.4, 86.2, and 76.8 s, respectively, compared to the control group (300 s). Tail wound bleeding times were similarly reduced with no significant difference between the hAM and the commercial hemostat (P values = 0.29, 0.34 in peritoneal and tail wounds, respectively). Neither hemostat affected coagulation time.ConclusionThis study describes a simple cost‐effective preparation protocol for a hAM‐based hemostatic agent. The long‐recognized safety, sustainability, and immunotolerance advantages of hAM can establish superiority over commercial hemostats with reported safety concerns. Robust research validation in larger‐scale bleeding models is required for wider applications and severe bleeding types.

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Investigating the hemostatic effect of medicinal plant Arnebia euchroma (Royle) I.M.Johnst extract in a mouse model

Cited by 8 publications

References 39 publications

Carbonized Platycladus orientalis Derived Carbon Dots Accelerate Hemostasis through Activation of Platelets and Coagulation Pathways

Carbonized Platycladus orientalis Derived Carbon Dots Accelerate Hemostasis through Activation of Platelets and Coagulation Pathways

Rational Design and Testing of Antibacterial Aloe Vera Hemostatic Hydrogel

Potential novel role of the human amniotic membrane as a sustainable hemostat

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