Most power systems' approaches are currently tending towards stochastic and probabilistic methods due to the high variability of renewable sources and the stochastic nature of loads. Conventional power flow (PF) approaches such as forward-backward sweep (FBS) and Newton-Raphson require a high number of iterations to solve non-linear PF equations making them computationally very intensive. PF is the most important study performed by utility, required in all stages of the power system, especially in operations and planning. This paper discusses the applications of deep learning (DL) to predict PF solutions for three-phase unbalanced power distribution grids. Three deep neural networks (DNNs); Radial Basis Function Network (RBFnet), Multi-Layer Perceptron (MLP), and Convolutional Neural Network (CNN), are proposed in this paper to predict PF solutions. The strength of the proposed DNN models over the traditional iterative-based PF solvers is that these models can capture the nonlinear relationships in PF calculations to accurately predict the solutions. The PF problem is formulated as a multi-output regression model where two or more output values are predicted based on the inputs. The training and testing data are generated through the OpenDSS-MATLAB COM interface. These methods are completely data-driven where the training relies on reducing the mismatch at each node without the need for the knowledge of the system. The novelty of the proposed methodology is that the models can accurately predict the PF solutions for the unbalanced distribution grids with mutual coupling and are robust to different R/X ratios, topology changes as well as generation and load variability introduced by the integration of distributed energy resources (DERs) and electric vehicles (EVs). To test the efficacy of the DNN models, they are applied to IEEE 4-node and 123-node test cases, and the American Electric Power (AEP) feeder model. The PF results for RBFnet, MLP, and CNN models are discussed in this paper which demonstrate that all three DNN models provide highly accurate results in predicting PF solutions.INDEX TERMS Power flow analysis, deep neural networks, radial basis function networks, multi-layer perceptron, convolutional neural networks, unbalanced power distribution grids.The associate editor coordinating the review of this manuscript and approving it for publication was Ehab Elsayed Elattar .