Airflow behavior and indoor/outdoor PM 2.5 dispersion in different building-tree grouping patterns depend significantly on the building-tree layouts and orientation towards the prevailing wind. By using a standard k-ε model and a revised generalized drift flux model, this study evaluated airflow fields and indoor/outdoor relationships for PM 2.5 resulting from partly wind-induced natural ventilation in four hypothetical building-tree grouping patterns. Results showed that: (1) Patterns provide a variety of natural ventilation potential that relies on the wind influence, and buildings that deflect wind on the windward facade and separate airflow on the leeward facade have better ventilation potential; (2) Patterns where buildings and trees form a central space and a windward opening side towards the prevailing wind offer the best ventilation conditions; (3) Under the assumption that transported pollution sources are diluted through the inlet, the aerodynamics and deposition effects of trees cause the lower floors of a multi-storey building to be exposed to lower PM 2.5 compared with upper floors, and lower indoor PM 2.5 values were found close to the tree canopy; (4) Wind pressure differences across each flat showed a poor correlation (R 2 = 0.059), with indoor PM 2.5 concentrations; and (5) Patterns with the long facade of buildings and trees perpendicular to the prevailing wind have the lowest indoor PM 2.5 concentrations.