Investigating the link between human resource strategic orientation and employee performance is the first of its kind in the area of human resource management. The main objective of this study is to investigate the effect of human resource strategic orientation on employee performance in the Federal Civil Service Commission, Abuja-Nigeria. This study adopted a primary survey research method. The population of the study is 400. The sample size is 196 using Krijcie and Morgan (1970). However, the study adopted Salkind's (1997) suggestion of increasing the sample size by 50%. Therefore, the final sample size is 294. The study adopted a stratified random sampling technique. Out of a total of 294 copies of the questionnaire administered and were duly returned. Hence, the number of 294 copies of the questionnaire was used for the analysis. The returned copies of the questionnaire were inputted, coded, and screened using Statistical Package for the Social Science (SPSS) version 22 software. The data were analyzed with the help of Partial Least Square Structural Equation Modelling (PLS-SEM). Hence, the study result showed that human resource strategic orientation is positive and significant to employee performance in Federal Civil Service Commission, Abuja-Nigeria. This study recommends that FCSC, Abuja-Nigeria, government, labour Unions and policymakers should promote human resource strategic orientation that will improve employee performance in FCSC, Abuja, and other related sectors in Nigeria to avoid agitations. The study also recommends the future researchers should adopt or adapt other dimensions of human resource management. The study further recommends that future studies should adopt or adapt the use of moderator and mediated variables which Africans and Nigerian researchers avoid. Finally, the study recommends the use of other methodological approaches and theoretical bases.