Investigating the Molecular Mechanisms Underlying Early Response to Inflammation and Helicobacter pylori Infection in Human Gastric Epithelial Cells

Martinelli, Giulia; Fumagalli, Marco; Piazza, Stefano; Maranta, Nicole; Genova, Francesca; Sperandeo, Paola; Sangiovanni, Enrico; Polissi, Alessandra; Dell’Agli, Mario; De Fabiani, Emma

doi:10.3390/ijms242015147

Cited by 2 publications

(3 citation statements)

References 43 publications

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“…The gastric epithelial cells are the first line of defense against H. pylori infection [ 19 ]. They activate immunocompetent cells through TLRs, which act as sensors for the bacterium.…”

Section: Interactions Of H Pylori With Cells Of Th...mentioning

confidence: 99%

Trained Immunity and Trained Tolerance: The Case of Helicobacter pylori Infection

Dore,

Pes

2024

IJMS

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Trained immunity is a concept in immunology in which innate immune cells, such as monocytes and macrophages, exhibit enhanced responsiveness and memory-like characteristics following initial contact with a pathogenic stimulus that may promote a more effective immune defense following subsequent contact with the same pathogen. Helicobacter pylori, a bacterium that colonizes the stomach lining, is etiologically associated with various gastrointestinal diseases, including gastritis, peptic ulcer, gastric adenocarcinoma, MALT lymphoma, and extra gastric disorders. It has been demonstrated that repeated exposure to H. pylori can induce trained immunity in the innate immune cells of the gastric mucosa, which become more responsive and better able to respond to subsequent H. pylori infections. However, interactions between H. pylori and trained immunity are intricate and produce both beneficial and detrimental effects. H. pylori infection is characterized histologically as the presence of both an acute and chronic inflammatory response called acute-on-chronic inflammation, or gastritis. The clinical outcomes of ongoing inflammation include intestinal metaplasia, gastric atrophy, and dysplasia. These same mechanisms may also reduce immunotolerance and trigger autoimmune pathologies in the host. This review focuses on the relationship between trained immunity and H. pylori and underscores the dynamic interplay between the immune system and the pathogen in the context of gastric colonization and inflammation.

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“…The gastric epithelial cells are the first line of defense against H. pylori infection [ 19 ]. They activate immunocompetent cells through TLRs, which act as sensors for the bacterium.…”

Section: Interactions Of H Pylori With Cells Of Th...mentioning

confidence: 99%

Trained Immunity and Trained Tolerance: The Case of Helicobacter pylori Infection

Dore,

Pes

2024

IJMS

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“…Accordingly, the derivatives of hydrolysis punicalin and ellagic acid were measured as well. The second phase of our study was aimed at investigating the bioactivity of CI in gastritis through a model of human non-tumoral gastric epithelial cells (GES-1) infected with H. pylori cag+ strain 26695 (ATCC ® ) [18]. The previous analytical data suggested that the stability of the polyphenolic fraction was partially affected by the gastric environment.…”

Section: Phytochemical Analysismentioning

confidence: 99%

“…Our group previously characterized the early inflammatory response of non-tumoral gastric cells (GES-1) to cag+ H. pylori infection [ 18 ]. By the same model, we suggested that extracts from Castanea sativa Mill.…”

Section: Introductionmentioning

confidence: 99%

Exploring In Vitro the Combination of Cistus × incanus L. and Castanea sativa Mill. Extracts as Food Supplement Ingredients against H. pylori Infection

Martinelli,

Fumagalli,

Pozzoli

et al. 2023

Foods

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Cistus spp. have been traditionally used for inflammatory and infectious disorders, including gastrointestinal ailments, in the Mediterranean area. Among them, Cistus × incanus L. is one of the most frequently cited species in the literature for a variety of biological activities which include inflammatory diseases. Cistus spp. aerial parts are rich in polyphenols such as condensed and hydrolysable tannins, procyanidins, and flavonoids, which show gastroprotective activities. The purpose of the present study is to investigate the biological activities of a hydroalcoholic extract from Cistus × incanus L. aerial parts in gastric epithelial cells (GES-1) infected with H. pylori. The extracts inhibited IL-8 and NF-κB induced by H. pylori and showed antibacterial activity after simulated digestion. Since our previous paper reported interesting results on the ability of Castanea sativa Mill. leaf extract to decrease inflammatory conditions in H. pylori-infected gastric cells, the combination of Castanea sativa and Cistus × incanus extracts was also investigated, showing strong anti-inflammatory activity and inhibition of bacterial adhesion. This association of botanicals is proposed herein as a novel food supplement capable of counteracting gastric inflammatory conditions.

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Investigating the Molecular Mechanisms Underlying Early Response to Inflammation and Helicobacter pylori Infection in Human Gastric Epithelial Cells

Cited by 2 publications

References 43 publications

Trained Immunity and Trained Tolerance: The Case of Helicobacter pylori Infection

Trained Immunity and Trained Tolerance: The Case of Helicobacter pylori Infection

Exploring In Vitro the Combination of Cistus × incanus L. and Castanea sativa Mill. Extracts as Food Supplement Ingredients against H. pylori Infection

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