Investigating the neuroprotective effect of AAV-mediated β-synuclein overexpression in a transgenic model of synucleinopathy

Sargent, Dorian; Bétemps, Dominique; Drouyer, Matthieu; Verchère, Jérémy; Gaillard, Damien; Arsac, Jean-Noël; Lakhdar, Latifa; Salvetti, Anna; Baron, Thierry

doi:10.1101/300822

Cited by 1 publication

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References 33 publications

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“…27 They also include beta-synuclein, which plays a detrimental role in Alzheimer's disease and Parkinson's disease. 28 Nevertheless, agents that have the potential to reduce excitotoxicity are currently under investigation as promising HIE therapies. 29…”

Section: Synaptic Proteinsmentioning

confidence: 99%

Proteomic profiles in cerebrospinal fluid predicted death and disability in term infants with perinatal asphyxia: A pilot study

et al. 2022

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Aim Perinatal asphyxia, resulting in hypoxic‐ischaemic encephalopathy (HIE), has been associated with high mortality rates and severe lifelong neurodevelopmental disabilities. Our aim was to study the association between the proteomic profile in cerebrospinal fluid (CSF) and the degree of HIE and long‐term outcomes. Methods We prospectively enrolled 18‐term born infants with HIE and 10‐term born controls between 2000 and 2004 from the Karolinska University Hospital. An antibody suspension bead array and FlexMap3D analysis was used to characterise 178 unique brain‐derived and inflammation associated proteins in their CSF. Results Increased CSF concentrations of several brain‐specific proteins were observed in the proteome of HIE patients compared with the controls. An upregulation of neuroinflammatory pathways was also noted and this was confirmed by pathway analysis. Principal component analysis revealed a gradient from favourable to unfavourable HIE grades and outcomes. The proteins that provided strong predictors were structural proteins, including myelin basic protein and alpha‐II spectrin. The functional proteins included energy‐related proteins like neuron‐specific enolase and synaptic regulatory proteins. Increased CSF levels of 51 proteins correlated with adverse outcomes in infants with HIE. Conclusion Brain‐specific proteins and neuroinflammatory mediators in CSF may predict HIE degrees and outcomes after perinatal asphyxia.

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Section: Synaptic Proteinsmentioning

confidence: 99%