The builavt environment has been a significant contributor to global carbon emissions. It, therefore, has a vital role to play in the reduction efforts of future climate change. While the design of buildings may determine future energy use for cooling, heating, and lighting during the operational stage of the building, this study aims to observe the effect of the building design on the operational as well as the whole-life carbon emissions. Past studies have focused on either the operational carbon or the embodied carbon of a building. Using a cradle-to-grave assessment of a typical UK supermarket, this study explores the relationship between embodied carbon and operational carbon. Additionally, it examines the effects of the variables between three approved construction methods of the same design on the whole life of carbon. These methods are a steel structural frame and cladding panel external wall, steel frame and poroton walls, precast concrete and glulam frame and precast concrete walls. The findings of this research will contribute to mitigation strategies for the environmental impacts of supermarket building construction whilst providing a framework for future assessment of the whole-life carbon of supermarket buildings. Employing the life cycle assessment methodology, this paper examines the potential of minimising both embodied and operational carbon by observing the whole life carbon. Highlighting the influence of the GHG emission contributing factors in each stage on each other. Additionally, the recommended methodology for the supermarket building types of this case study, could be adapted for other types of buildings. The findings could also augment carbon emission research and guide the development of supermarket buildings to low carbon intensive. Furthermore, collaboration with the industry in carrying out this research aids in adopting the findings as practical and theoretical guides for engineers and designers in reducing the building sector’s harmful environmental impact.