Investigating the potential of human placenta-derived extracellular matrix sponges coupled with amniotic membrane-derived stem cells for osteochondral tissue engineering

Abstract

Placental extracellular matrix for osteochondral defects.

Cocktail of Hyaluronic Acid and Human Amniotic Mesenchymal Cells Effectively Repairs Cartilage Injuries in Sodium Iodoacetate-Induced Osteoarthritis Rats

“…There are studies reporting that the use of MSCs alone to treat cartilage injury has very limited effect (Dhinsa and Adesida, 2012). In contrast, other studies have shown that MSCs play an important role in relieving pain, delaying the onset of arthritis, and repairing cartilage damage (Dhinsa and Adesida, 2012;Rameshbabu et al, 2016). In the present study, we found that compared with the MG group, hAMSCs alone had a certain ability to repair cartilage damage in HTG group, comparable to that of using HA alone in the HG group.…”

“…Recently, in vitro models have demonstrated that hAMSCs are favorable sources of cartilage repair (Muiños-López et al, 2017;Topoluk et al, 2017Topoluk et al, , 2018. However, to date, reports on hAMSCs-based cartilage repair in vivo are rare, and to our knowledge, studies on the injection treatment of cartilage damage in vivo by hAMSCs have not been reported (Rameshbabu et al, 2016).…”

Decellularized Human Chorion Membrane as a Novel Biomaterial for Tissue Regeneration

“…So, one way to obtain ECM proteins and avoid a host adverse immune response when implanted in vivo is through tissue decellularization [14][15][16][17][18]. In fact, the human placenta has been fully decellularized through the creation of ECM suspensions to further create membranes [19] or sponges [20]. In these works, the various components of the human placenta are not differentiated, such as the human amniotic membrane (HAM) and the human chorion membrane (HCM) [21].…”

Human Placenta Hydrolysate Promotes Liver Regeneration <i>via</i> Activation of the Cytokine/Growth Factor-Mediated Pathway and Anti-oxidative Effect

“…8,9) Many of these factors possibly act in an autocrine and/or paracrine fashion within the human placenta and regulate the production of other biologically active substances, which may hold potential for therapeutic agents as suggested in previous studies, where fractions of human placenta hydrolysate (hPH) stimulated tissue repair processes. 10,11) Over the last few decades, hPH has been prescribed clinically to treat chronic hepatitis, 12,13) liver cirrhosis 14) and other hepatic diseases. 15) hPH reportedly ameliorated hepatic injury through liver regeneration 9) and inhibited inflammatory reactions and apoptosis.…”