Investigating the potential of Oxymatrine as a psoriasis therapy

Chen, Qian; Zhou, Hui; Yang, Yinxue; Chi, Mingwei; Xie, Nan; Zhang, Hong; Deng, Xingwang; Leavesley, David I.; Shi, Huijuan; Xie, Yun

doi:10.1016/j.cbi.2017.04.020

Cited by 24 publications

(12 citation statements)

References 65 publications

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“…This suggestion seems to be borne out in practice (Saxena and Dogra, 2005, 2010; Walecka et al, 2009). Finally, if inflammation is a cause and not a manifestation, one may anticipate that anti-inflammatories might also be of value (Aggarwal and Harikumar, 2008; Kang et al, 2016; Chen et al, 2017; Sharma et al, 2017; Kerley et al, 2018; Owczarczyk-Saczonek et al, 2018).…”

Section: Implications For Treatmentmentioning

confidence: 99%

Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris

Visser

Kell

Pretorius

2019

Front. Cell. Infect. Microbiol.

113

105

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Psoriasis vulgaris is a chronic inflammatory skin condition, associated with both a physical and a psychological burden. Our understanding of the etiology of this disease remains incomplete. Conventionally, psoriasis has been viewed as a condition that manifests solely in the skin. However, the systemic inflammatory nature of this disease has been confirmed by the presence of a wide array of dysregulated cytokines and inflammatory markers in the serum of these patients. Both dysregulated gut and skin microbiomes have been found in association with psoriasis. An evident association also exists between inflammatory bowel disease and this condition. Regarding the skin microbiome, changes have been observed in the relative abundance of Firmicutes, Actinobacteria, and Proteobacteria. Additionally, Staphylococcus and Streptococcus spp. were detected more frequently in lesional skin. Alterations in the gut microbiome have been characterized by a decrease in the Bacteroidetes phylum and an increase in the Faecalibacterium genus. We suggest that dysbiosis of the skin and gut microbiota may contribute to psoriasis, by promoting the translocation of microbes from these sites into the bloodstream. Consistent with the Iron Dysregulation and Dormant Microbes hypothesis, these microorganisms are in a physiologically dormant state, but may be awakened periodically and shed their cell wall components, such as lipopolysaccharide and lipoteichoic acid. Both of these inflammagens may contribute significantly to maintaining a chronic inflammatory state in the host, such as is seen in individuals diagnosed with psoriasis.

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Section: Implications For Treatmentmentioning

confidence: 99%

Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris

Visser

Kell

Pretorius

2019

Front. Cell. Infect. Microbiol.

113

105

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“…Matrine synergized with acitretin to induce cell cycle arrest and autophagy in keratinocytes by regulating PI3K/Akt/mTOR pathway (Jiang et al, 2019). Oxymatrine ameliorated skin inflammation in the patients with psoriasis and psoriasis-like mouse model via inhibiting keratinocyte proliferation probably through MAPK signaling pathway (Chen et al, 2017;Zhou et al, 2017;Shi et al, 2019;Xiang et al, 2020). Whether Kushen or its active components influence T cell biology remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Xiao-Yin-Fang Therapy Alleviates Psoriasis-like Skin Inflammation Through Suppressing γδT17 Cell Polarization

Zhang

Chen

et al. 2021

Front. Pharmacol.

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Psoriasis is an immune-mediated chronic inflammatory skin disease primarily mediated by the activation of interleukin (IL)-17-producing T cells. Traditional Chinese Medicine (TCM) represents one of the most effective complementary and alternative medicine (CAM) agents for psoriasis, which provides treasured sources for the development of anti-psoriasis medications. Xiao-Yin-Fang (XYF) is an empirically developed TCM formula that has been used to treat psoriasis patients in Shanghai Changhai Hospital for over three decades. Imiquimod (IMQ)-induced psoriasis-like dermatitis mouse model was utilized to investigate the therapeutic effects of XYF by the assessment of disease severity and skin thickness. Flow cytometric assay was performed to explore the influence of XYF on skin-related immunocytes, primarily T cells. And, RNA sequencing analysis was employed to determine the alternation in gene expression upon XYF therapy. We discovered that XYF alleviated psoriasis-like skin inflammation mainly through suppressing dermal and draining lymph-node IL-17-producing γδT (γδT17) cell polarization. Moreover, XYF therapy ameliorated the relapse of psoriasis-like dermatitis and prohibited dermal γδT cell reactivation. Transcriptional analysis suggested that XYF might regulate various inflammatory signaling pathways and metabolic processes. In conclusion, our results clarified the therapeutic efficacy and inner mechanism of XYF therapy in psoriasis, which might promote its clinical application in psoriasis patients and facilitate the development of novel anti-psoriasis drugs based on the bioactive components of XYF.

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“…Oxymatrine, an active component of Sophora flavescens, showed excellent anti-inflammatory and anti-psoriatic effects. To investigate the potential of oxymatrine in the treatment of psoriasis, Chen et al (Chen et al, 2017b) gathered 150 patients clinically diagnosed with psoriasis vulgaris from both inpatient and outpatient clinics. They were given 600 mg/kg oxymatrine intravenously for 4 weeks.…”

Section: Alkaloidsmentioning

confidence: 99%

Advances in the Application of Natural Products and the Novel Drug Delivery Systems for Psoriasis

Xie

Huang

et al. 2021

Front. Pharmacol.

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Psoriasis, an incurable autoimmune skin disease, is one of the most common immune-mediated disorders. Presently, numerous clinical research studies are underway, and treatment options are available. However, these treatments focus on improving symptoms of the disease and fail to achieve a radical cure; they also have certain toxic side effects. In recent years, natural products have increasingly gained attention because of their high efficiency and low toxicity. Despite their obvious therapeutic effects, natural products’ biological activity was limited by their instability, poor solubility, and low bioavailability. Novel drug delivery systems, including liposomes, lipospheres, nanostructured lipid carriers, niosomes, nanoemulsions, nanospheres, microneedles, ethosomes, nanocrystals, and foams could potentially overcome the limitations of poor water solubility and permeability in traditional drug delivery systems. Thus, to achieve a therapeutic effect, the drug can reach the epidermis and dermis in psoriatic lesions to interact with the immune cells and cytokines.

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Investigating the potential of Oxymatrine as a psoriasis therapy

Cited by 24 publications

References 65 publications

Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris

Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris

Xiao-Yin-Fang Therapy Alleviates Psoriasis-like Skin Inflammation Through Suppressing γδT17 Cell Polarization

Advances in the Application of Natural Products and the Novel Drug Delivery Systems for Psoriasis

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