Investigating the predictors of happiness, life satisfaction and success in schizophrenia

Saperia, Sarah; Silva, Susana Da; Siddiqui, Ishraq; McDonald, Krysta; Agid, Ofer; Remington, Gary; Foussias, George

doi:10.1016/j.comppsych.2017.11.005

Cited by 27 publications

(29 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The current findings do not support this view and instead suggest that, although the control of positive symptoms with antipsychotics may be important, the negative symptoms that often remain may have the strongest influence on individuals’ perception of their mental health, second only to affective symptoms. This profound influence of negative symptoms is further reinforced by the findings from 2 recent studies of patients with schizophrenia, where negative symptoms were found to be strongly negatively associated with subjective well-being [29, 30]. …”

Section: Discussionsupporting

confidence: 49%

Psychopathological Symptoms and Satisfaction with Mental Health in Patients with Schizophrenia

2018

View full text Add to dashboard Cite

Background: The patient’s view of their mental health is a central aspect in research and practice. Yet, little is known about which psychopathological symptoms are linked with patients’ satisfaction with their mental health. We aimed to identify these symptoms in patients with schizophrenia. Methods: An individual patient data meta-analysis was conducted with data from 2,488 patients from 8 independent studies. Satisfaction with mental health was rated on a 7-point scale, and symptoms were observer-rated using identical items from the Brief Psychiatric Rating Scale and the Positive and Negative Symptom Scale. Mixed multilevel univariate followed by multivariate regression models were used to identify symptoms associated with satisfaction with mental health. Results: In univariate regressions, all subscales – not age and gender – were associated with mental health satisfaction. In the multivariate regression, only affective and negative symptoms were significantly associated with a lower satisfaction with mental health, explaining 22.5% of the variance. Conclusions: Observer-rated psychopathological symptoms are linked to patients’ mental health satisfaction. In addition to affective symptoms – which are commonly negatively linked with satisfaction ratings – a higher level of negative symptoms makes patients less satisfied with their mental health, whilst positive and other symptoms do not influence mental health satisfaction.

show abstract

Section: Discussionsupporting

confidence: 49%

Psychopathological Symptoms and Satisfaction with Mental Health in Patients with Schizophrenia

2018

View full text Add to dashboard Cite

show abstract

“…Patients with schizophrenia suffer from motivational deficits that are driven by difficulties in anticipating benefits and a reduction in allocating effort. Decreased effort allocation is particularly important because it inversely predicts functionality [8], happiness, life satisfaction and success [4]. Here we demonstrate that in mice, overexpression of striatal D2 receptors specifically impacts effort-based choice and is association with dampened extracellular dopamine during goal-directed activity.…”

Section: Discussionmentioning

confidence: 58%

“…Impaired goal-directed motivation is a debilitating symptom impacting many individuals with schizophrenia [1][2][3][4]. Diminished motivation is associated with deficits in cost-benefit decision making with patients haveing difficulty generating accurate estimates of the value of future rewards [5][6][7] or difficulty estimating the effort required to complete tasks [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Striatal dopamine D2 receptors regulate effort but not value-based decision making and alter the dopaminergic encoding of cost

Filla

Bailey

Schipani

et al. 2018

Neuropsychopharmacol

View full text Add to dashboard Cite

Deficits in goal-directed motivation represent a debilitating symptom for many patients with schizophrenia. Impairments in motivation can arise from deficits in processing information about effort and or value, disrupting effective cost-benefit decision making. We have previously shown that upregulated dopamine D2 receptor expression within the striatum (D2R-OE mice) decreases goal-directed motivation. Here, we determine the behavioral and neurochemical mechanisms behind this deficit. Female D2R-OE mice were tested in several behavioral paradigms including recently developed tasks that independently assess the impact of Value or Effort manipulations on cost-benefit decision making. In vivo microdialysis was used to measure extracellular dopamine in the striatum during behavior. In a value-based choice task, D2R-OE mice show normal sensitivity to changes in reward value and used reward value to guide their actions. In an effort-based choice task, D2R-OE mice evaluate the cost of increasing the number of responses greater relative to the effort cost of longer duration responses compared to controls. This shift away from choosing to repeatedly execute a response is accompanied by a dampening of extracellular dopamine in the striatum during goal-directed behavior. In the ventral striatum, extracellular dopamine level negatively correlates with response cost in controls, but this relationship is lost in D2R-OE mice. These results show that D2R signaling in the striatum, as observed in some patients with schizophrenia, alters the relationship between effort expenditure and extracellular dopamine. This dysregulation produces motivation deficits that are specific to effort but not value-based decision making, paralleling the effort-based motivational deficits observed in schizophrenia.

show abstract

“…We were unable to establish what informed this difference as other factors that are reported as impacting on wellbeing outcomes, including the impact of negative symptoms, e.g. motivation and depression [ 49 – 51 ] and having a greater number of unmet needs [ 52 – 54 ] were not reported in all of the included studies.…”

Section: Discussionmentioning

confidence: 99%

Quality of life outcomes for people with serious mental illness living in supported accommodation: systematic review and meta-analysis

Harrison

Roy

Hultqvist

et al. 2020

Soc Psychiatry Psychiatr Epidemiol

View full text Add to dashboard Cite

Purpose To conduct a systematic review and meta-analysis of quality of life (QoL) outcomes for people with serious mental illness living in three types of supported accommodation. Methods Studies were identified that described QoL outcomes for people with serious mental illness living in supported accommodation in six electronic databases. We applied a random-effects model to derive the meta-analytic results. Results 13 studies from 7 countries were included, with 3276 participants receiving high support (457), supported housing (1576) and floating outreach (1243). QoL outcomes related to wellbeing, living conditions and social functioning were compared between different supported accommodation types. Living condition outcomes were better for people living in supported housing (g = − 0.31; CI = [− 0.47; − 0.16]) and floating outreach (g = − 0.95; CI = [− 1.30; − 0.61]) compared to high-support accommodation, with a medium effect size for living condition outcomes between supported housing and floating outreach (g = − 0.40; CI = [− 0.82; 0.03]), indicating that living conditions are better for people living in floating outreach. Social functioning outcomes were significant for people living in supported housing compared to high support (g = − 0.37; CI = [− 0.65; − 0.09]), with wellbeing outcomes not significant between the three types of supported accommodation. Conclusion There is evidence that satisfaction with living conditions differs across supported accommodation types. The results suggest there is a need to focus on improving social functioning and wellbeing outcomes for people with serious mental illness across supported accommodation types.

show abstract

Investigating the predictors of happiness, life satisfaction and success in schizophrenia

Cited by 27 publications

References 50 publications

Psychopathological Symptoms and Satisfaction with Mental Health in Patients with Schizophrenia

Psychopathological Symptoms and Satisfaction with Mental Health in Patients with Schizophrenia

Striatal dopamine D2 receptors regulate effort but not value-based decision making and alter the dopaminergic encoding of cost

Quality of life outcomes for people with serious mental illness living in supported accommodation: systematic review and meta-analysis

Contact Info

Product

Resources

About