Investigating the Relationships Between Alcohol Consumption, Cannabis Use, and Circulating Cytokines: A Preliminary Analysis

Karoly, Hollis C.; Bidwell, L. Cinnamon; Mueller, Raeghan L.; Hutchison, Kent E.

doi:10.1111/acer.13592

Cited by 25 publications

(26 citation statements)

References 47 publications

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“…In contrast, cannabis produces anti‐inflammatory actions (Nair et al., ), and it is of great interest to determine if any of the detrimental effects of alcohol can be ameliorated by exo‐ or endocannabinoids. As discussed in this Virtual Issue, studies in animal models report protective effects of CBD on alcohol‐induced neurodegeneration and alcohol‐induced liver steatosis, and human studies suggest a relationship between co‐use of cannabis and alcohol on immune function and inflammation (Karoly et al., ; Turna et al., ). To further examine cannabis–alcohol interactions in humans, Karoly and colleagues () determined if plasma levels of proinflammatory cytokines were associated with alcohol and cannabis use.…”

Section: Possible Benefits Of Co‐use Of Alcohol With Cannabis or Cannmentioning

confidence: 99%

“…As discussed in this Virtual Issue, studies in animal models report protective effects of CBD on alcohol‐induced neurodegeneration and alcohol‐induced liver steatosis, and human studies suggest a relationship between co‐use of cannabis and alcohol on immune function and inflammation (Karoly et al., ; Turna et al., ). To further examine cannabis–alcohol interactions in humans, Karoly and colleagues () determined if plasma levels of proinflammatory cytokines were associated with alcohol and cannabis use. They found a positive association for interleukin‐6 and alcohol use, and the association was stronger in cannabis nonuse groups compared with use groups.…”

Section: Possible Benefits Of Co‐use Of Alcohol With Cannabis or Cannmentioning

confidence: 99%

See 1 more Smart Citation

Cannabis and Alcohol: From Basic Science to Public Policy

Chung

Harris

2019

Alcoholism Clin & Exp Res

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Section: Possible Benefits Of Co‐use Of Alcohol With Cannabis or Cannmentioning

confidence: 99%

Section: Possible Benefits Of Co‐use Of Alcohol With Cannabis or Cannmentioning

confidence: 99%

Cannabis and Alcohol: From Basic Science to Public Policy

Chung

Harris

2019

Alcoholism Clin & Exp Res

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“…Finally, although we asked participants not to use drugs and alcohol 48 hours before each measurement and we checked this by verbally asking them whether they used alcohol or drugs, we cannot be entirely sure that participants did not violate these rules. As consumption of alcohol and drugs can alter cytokine responses [ 66 ], future research should include quantification of alcohol and drug consumption with objective tests.…”

Section: Discussionmentioning

confidence: 99%

An Internet-Based Psychological Intervention With a Serious Game to Improve Vitality, Psychological and Physical Condition, and Immune Function in Healthy Male Adults: Randomized Controlled Trial

Schakel¹,

Veldhuijzen²,

Middendorp³

et al. 2020

J Med Internet Res

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Background Recently, internet-based cognitive behavioral therapy (ICBT) and serious gaming interventions have been suggested to enhance accessibility to interventions and engagement in psychological interventions that aim to promote health outcomes. Few studies, however, have investigated their effectiveness in the context of simulated real-life challenges. Objective We aimed to examine the effectivity of a guided ICBT combined with a serious gaming intervention in improving self-reported psychophysiological and immunological health endpoints in response to psychophysiological and immune-related challenges. Methods Sixty-nine healthy men were randomly assigned to the intervention condition, receiving ICBT combined with serious gaming for 6 weeks, or the control condition, receiving no intervention. Self-reported vitality was the primary endpoint. Other self-reported psychophysiological and immunological endpoints were assessed following various challenges, including a bacillus Calmette-Guérin vaccination evoking pro-inflammatory responses, 1 and 4 weeks after the intervention period. Results Although the intervention did not affect vitality-associated parameters, self-reported sleep problems (P=.027) and bodily sensations (P=.042) were lower directly after the intervention compared with controls. Furthermore, wellbeing (P=.024) was higher in the intervention group after the psychophysiological challenges. Although no significant group differences were found for the psychophysiological and immunological endpoints, the data provided preliminary support for increased immunoglobulin antibody responses at the follow-up time points (P<.05). Differential chemokine endpoints between conditions were observed at the end of the test day. Conclusions The present study provides some support for improving health endpoints with an innovative ICBT intervention. Future research should replicate and further extend the present findings by consistently including challenges and a wide range of immune parameters into the study design. Trial Registration Nederlands Trial Register NTR5610; https://www.trialregister.nl/trial/5466

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“…We examined the following variables as potential confounding factors that could explain differences between patients and controls in serum cytokine and chemokine levels: age and sex 19 , BMI 20 , smoking 21 , cannabis use 22 , sample storage time 23 , and antipsychotic medication, analyzing the potential effects of different antipsychotics and the chlorpromazine equivalent dose 24 .…”

Section: Potential Confounding Factorsmentioning

confidence: 99%

Elevated serum chemokine CCL22 levels in first-episode psychosis: associations with symptoms, peripheral immune state and in vivo brain glial cell function

et al. 2020

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Several lines of research support immune system dysregulation in psychotic disorders. However, it remains unclear whether the immunological marker alterations are stable and how they associate with brain glial cell function. This longitudinal study aimed at investigating whether peripheral immune functions are altered in the early phases of psychotic disorders, whether the changes are associated with core symptoms, remission, brain glial cell function, and whether they persist in a one-year follow-up. Two independent cohorts comprising in total of 129 first-episode psychosis (FEP) patients and 130 controls were assessed at baseline and at the one-year follow-up. Serum cyto-/ chemokines were measured using a 38-plex Luminex assay. The FEP patients showed a marked increase in chemokine CCL22 levels both at baseline (p < 0.0001; Cohen's d = 0.70) and at the 12-month follow-up (p = 0.0007) compared to controls. The group difference remained significant (p = 0.0019) after accounting for relevant covariates including BMI, smoking, and antipsychotic medication. Elevated serum CCL22 levels were significantly associated with hallucinations (ρ = 0.20) and disorganization (ρ = 0.23), and with worse verbal performance (ρ = −0.23). Brain glial cell activity was indexed with positron emission tomography and the translocator protein radiotracer [ 11 C]PBR28 in subgroups of 15 healthy controls and 14 FEP patients with serum CCL22/CCL17 measurements. The distribution volume (V T) of [ 11 C] PBR28 was lower in patients compared to controls (p = 0.026; Cohen's d = 0.94) without regionally specific effects, and was inversely associated with serum CCL22 and CCL17 levels (p = 0.036). Our results do not support the over-active microglia hypothesis of psychosis, but indicate altered CCR4 immune signaling in early psychosis with behavioral correlates possibly mediated through cross-talk between chemokine networks and dysfunctional or a decreased number of glial cells.

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Investigating the Relationships Between Alcohol Consumption, Cannabis Use, and Circulating Cytokines: A Preliminary Analysis

Cited by 25 publications

References 47 publications

Cannabis and Alcohol: From Basic Science to Public Policy

Cannabis and Alcohol: From Basic Science to Public Policy

An Internet-Based Psychological Intervention With a Serious Game to Improve Vitality, Psychological and Physical Condition, and Immune Function in Healthy Male Adults: Randomized Controlled Trial

Elevated serum chemokine CCL22 levels in first-episode psychosis: associations with symptoms, peripheral immune state and in vivo brain glial cell function

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