Investigating the Response of Human Neutrophils to Hydrophilic and Hydrophobic Micro-Rough Titanium Surfaces

Kholy, Karim El; Buser, Daniel; Wittneben, Julia‐Gabriela; Bosshardt, Dieter D.; Dyke, Thomas E. Van; Kowolik, Michael

doi:10.3390/ma13153421

Cited by 13 publications

(11 citation statements)

References 38 publications

(41 reference statements)

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“…Ten studies assessed the interaction of neutrophils with titanium surfaces based on their roughness. One study identified intact cellular morphology and reduced chemiluminescence activity (respiratory burst) by neutrophils when interacting with serum coated moderately rough hydrophilic titanium surfaces compared to moderately rough hydrophobic titanium surfaces (El Kholy et al, 2020). A second study identified neutrophils interacting with rough hydrophilic titanium surfaces to produce low levels of interleukin‐1β (IL‐1β), IL‐6, IL‐12, tumor necrosis factor‐α, IL, neutrophils elastase, and myeloperoxidase with no NETs formation compared to neutrophils interacting with naive smooth and rough titanium surfaces (Abaricia et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

“…Studies have also identified different neutrophil morphology and NETotic responses to titanium surfaces with various roughness fields (Abaricia et al, 2020; Vitkov et al, 2015). Furthermore, researchers have investigated neutrophil interaction with implant surfaces having a combination of roughness/hydrophilicity, which may promote quicker healing time and reduced initial inflammatory response (Abaricia et al, 2020; El Kholy et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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A systematic review on neutrophils interactions with titanium and zirconia surfaces: Evidence from in vitro studies

Figueredo

2022

Clinical & Exp Dental Res

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Objectives: This systematic review aimed to assess in vitro studies that evaluated neutrophil interactions with different roughness levels in titanium and zirconia implant surfaces.Material and Methods: An electronic search for literature was conducted on PubMed, Embase, Scopus, and Web of Science and a total of 14 studies were included.Neutrophil responses were assessed based on adhesion, cell number, surface coverage, cell structure, cytokine secretion, reactive oxygen species (ROS) production, neutrophil activation, receptor expression, and neutrophil extracellular traps (NETs) release. The method of assessing the risk of bias was done using the toxicological data reliability assessment tool (TOXRTOOL).Results: Ten studies have identified a significant increase in neutrophil functions, such as surface coverage, cell adhesion, ROS production, and NETs released when interacting with rough titanium surfaces. Moreover, neutrophil interaction with rough-hydrophilic surfaces seems to produce less proinflammatory cytokines and ROS when compared to naive smooth and rough titanium surfaces. Regarding membrane receptor expression, two studies have reported that the FcγIII receptor (CD16) is responsible for initial neutrophil adhesion to hydrophilic titanium surfaces. Only one study compared neutrophil interaction with titanium alloy and zirconia toughened alumina surfaces and reported no significant differences in neutrophil cell count, activation, receptor expression, and death.Conclusions: There are not enough studies to conclude neutrophil interactions with titanium and zirconia surfaces. However, different topographic modifications such as roughness and hydrophilicity might influence neutrophil interactions with titanium implant surfaces.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A systematic review on neutrophils interactions with titanium and zirconia surfaces: Evidence from in vitro studies

Figueredo

2022

Clinical & Exp Dental Res

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“…Along these lines, the leucocyte concentration was found to increase after surgery in the blood levels of all patients ( Table 2 ). Neutrophils, together with basophils and eosinophils, belong to polymorphonuclear leukocytes, constitute 40–65% of the white blood cell population and are hallmarks of acute inflammation [ 43 , 44 ]. Immediately following tissue injury, these cells are recruited and exert anti-microbial activity via degranulation, enzymatic release, phagocytosis of foreign substances and debris and the production of large DNA-based fiber networks called neutrophil extracellular traps [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

The Implant Proteome—The Right Surgical Glue to Fix Titanium Implants In Situ

Jäger

Latosinska

Herten

et al. 2022

JFB

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Titanium implants are frequently applied to the bone in orthopedic and trauma surgery. Although these biomaterials are characterized by excellent implant survivorship and clinical outcomes, there are almost no data available on the initial protein layer binding to the implant surface in situ. This study aims to investigate the composition of the initial protein layer on endoprosthetic surfaces as a key initiating step in osseointegration. In patients qualified for total hip arthroplasty, the implants are inserted into the femoral canal, fixed and subsequently explanted after 2 and 5 min. The proteins adsorbed to the surface (the implant proteome) are analyzed by liquid chromatography–tandem mass spectrometry (LC-MS/MS). A statistical analysis of the proteins’ alteration with longer incubation times reveals a slight change in their abundance according to the Vroman effect. The pathways involved in the extracellular matrix organization of bone, sterile inflammation and the beginning of an immunogenic response governed by neutrophils are significantly enriched based on the analysis of the implant proteome. Those are generally not changed with longer incubation times. In summary, proteins relevant for osseointegration are already adsorbed within 2 min in situ. A deeper understanding of the in situ protein–implant interactions in patients may contribute to optimizing implant surfaces in orthopedic and trauma surgery.

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“…Hydrophilic: # recruitment # ROS [198] Hydrophobic/cationic surfaces: " adhesion, FBGC fusion [72] (modified PET surfaces)…”

Section: Surface Wettability/ Chargementioning

confidence: 99%

Progress in Vocal Fold Regenerative Biomaterials: An Immunological Perspective

Coburn

et al. 2021

Advanced NanoBiomed Research

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The vocal folds are functional organs located in the larynx that play a critical role in our daily breathing, speech, and swallowing functions. A key structural feature of the vocal folds is their delicate mucosa, which consists of a thin, layered epithelium and underlying extracellular matrix (ECM)-rich lamina propria. [1,2] Irreversible changes to the vocal fold mucosa, such as scarring, atrophy, and sulcus vocalis, require regenerative technologies to stimulate a controlled regrowth of the tissue. An increasing number of biomaterial systems have been proposed with the concurrent capability of refilling and regenerating severely damaged or absent vocal fold mucosae in situ (see review on public health significance in the study by Green et al. [3] ).Notably, as the vocal folds are located at the narrowest point of the airway, adverse hostÀbiomaterial responses can impair upper airway patency and create life-threatening complications. For instance, 2À5% of patients were reported to have postoperative inflammatory reactions including edema, dysphonia, and dyspnea to injectable biomaterials derived from hyaluronic acid (HA). [4][5][6] Although the incidence is rare, severe airway reactions could lead to an emergency admission for intensive care and require intubation procedures for breathing support. [5,7] Inevitably, this immunemediated rejection response is detrimental to the longevity, performance, and integration of the biomaterial in the vocal fold mucosa.Upon biomaterial introduction into a host, the immune system quickly responds to the iatrogenic trauma and foreign

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Investigating the Response of Human Neutrophils to Hydrophilic and Hydrophobic Micro-Rough Titanium Surfaces

Cited by 13 publications

References 38 publications

A systematic review on neutrophils interactions with titanium and zirconia surfaces: Evidence from in vitro studies

A systematic review on neutrophils interactions with titanium and zirconia surfaces: Evidence from in vitro studies

The Implant Proteome—The Right Surgical Glue to Fix Titanium Implants In Situ

Progress in Vocal Fold Regenerative Biomaterials: An Immunological Perspective

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