Lightning injuries, deaths, and the economic consequences of lightning damage to property and infrastructure continue to be a significant public health challenge and economic development issue in many tropical and subtropical areas of the world, especially sub-Saharan Africa. This chapter will discuss the scope of the hazard, known risk factors including common cultural beliefs that inhibit public education, existing data sources, medical effects and long-term disability, lightning formation and detection, injury mechanisms, existing lightning safety programs and their challenges, and the work being done to decrease injuries, death, and property damage from lightning in Africa by the African Centres for Lightning and Electromagnetics Network (ACLENet).