Investigating the role of osteoprotegerin gene polymorphic variants in osteoporosis

Abstract

In recent genome-wide association studies (GWAS), several polymorphic loci of the osteoprotegerin (OPG) gene were significantly associated with bone mineral density (BMD) and fractures in men over 50 years of age and postmenopausal women. The objective of our study was to search for associations of rs3102735, rs3134069, rs2073617, rs2073618, rs3102734 and rs7844539 of the OPG gene with the risk of osteoporotic fractures and the level of BMD in individual and comorbid conditions in men and women from the Volga-Ural region of Russia. Material and Methods — 828 women and 496 men of various ethnic groups (Russians, Turks) were examined using two-energy x-ray absorptiometry (DEXA) in the femoral neck and lumbar spine. 1324 deoxyribonucleic acid (DNA) samples were genotyped using a fluorescent endpoint genotyping system, after that we searched for associations of these polymorphic loci with fractures and low BMD levels of various localizations. As a result, there was a significant association of rs3134069 and rs3102734 with fractures in general and in the peripheral parts of the skeleton, as well as rs7844539 and rs3102734 in women and rs2073618 in men with low BMD. Another significant association of rs3102734 and rs2073618 with low bone mineral density in the femoral neck was found in both genders. Conclusion — Polymorphic variants rs3134069, rs3102734, rs7844539 and rs3102734 are potential markers of the risk of osteoporetic fractures and the formation of low BMD in men and women from the Volga-Ural region of Russia.

Osteoprotegerin genetic polymorphisms and their influence on therapeutic response to ibandronate in postmenopausal osteoporotic females

“…A Russian study reported that polymorphic OPG rs3134069, rs3102734, rs7844539, and rs3102734 are prospective risk markers for osteoporotic fractures and low BMD in men and women population. They found no link between rs3102735, rs2073618 of the OPG gene and osteoporotic fractures risk and the BMD level [ 4 ]. A recent MA indicated a link between the T245G polymorphism and osteoporosis risk.…”

“…Different studies have documented that single nucleotide polymorphisms (SNPs) in TNFRSF11B (OPG) genes are correlated with a decrease in BMD and fracture risk [ 3 , 4 ]. The OPG gene is believed to engage in the pathogenesis of osteoporosis [ 5 ].…”

Epigenetic regulation of bone remodeling and its role in the pathogenesis of primary osteoporosis

“…Primary osteoporosis (OP) is an age-associated disease of multifactorial aetiology, which is based on a violation of the balance of bone remodelling, leading to a decrease in the level of bone mineral density (BMD) and a violation of the structure of bone microarchitectonics, which result in the appearance of an incorrect spatial structure of the spongy and cortical bone (Yalaev et al, 2021). Bone mass is reduced to 26 % in individuals predisposed to OP.…”