Investigating the safety of capsaicin cough challenge in severe asthma

Wang, Ran; Fowler, Stephen J.; Niven, Rob; Ryan, Dorothy; Holt, Kimberley; Mitchell, Joanne; Dockry, Rachel; Al-Sheklly, Bashar; Satia, Imran; Smith, Jaclyn A.

doi:10.1111/cea.13392

Cited by 14 publications

(12 citation statements)

References 9 publications

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“…Consistent with mild to moderate patients, female patients coughed more and at lower concentrations of capsaicin. However, this was only in 8 patients with large variations in symptom scores after the cough challenge, and four patients requested salbutamol for symptoms despite no significant fall in FEV 1 (41).…”

Section: Update On Chronic Coughmentioning

confidence: 93%

Airways diseases: asthma, COPD and chronic cough highlights from the European Respiratory Society Annual Congress 2018

et al. 2018

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Section: Update On Chronic Coughmentioning

confidence: 93%

Airways diseases: asthma, COPD and chronic cough highlights from the European Respiratory Society Annual Congress 2018

et al. 2018

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“…A study published in 2020 tested the effects of inhaled capsaicin on 385 chronic cough patients, revealing that the capsaicin cough challenge is a proper method for investigating patients with variable clinical factors in asthma ( 174 ). Additionally, the test is a safe method to employ in severe asthma ( 175 ).…”

Section: Capsaicin In Asthmamentioning

confidence: 99%

Comparative effects of capsaicin in chronic obstructive pulmonary disease and asthma (Review)

et al. 2021

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Chronic obstructive pulmonary disease (COPD) and asthma are chronic respiratory diseases with high prevalence and mortality that significantly alter the quality of life in affected patients. While the cellular and molecular mechanisms engaged in the development and evolution of these two conditions are different, COPD and asthma share a wide array of symptoms and clinical signs that may impede differential diagnosis. However, the distinct signaling pathways regulating cough and airway hyperresponsiveness employ the interaction of different cells, molecules, and receptors. Transient receptor potential cation channel subfamily V member 1 (TRPV1) plays a major role in cough and airway inflammation. Consequently, its agonist, capsaicin, is of substantial interest in exploring the cellular effects and regulatory pathways that mediate these respiratory conditions. Increasingly more studies emphasize the use of capsaicin for the inhalation cough challenge, yet the involvement of TRPV1 in cough, bronchoconstriction, and the initiation of inflammation has not been entirely revealed. This review outlines a comparative perspective on the effects of capsaicin and its receptor in the pathophysiology of COPD and asthma, underlying the complex entanglement of molecular signals that bridge the alteration of cellular function with the multitude of clinical effects.

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“…Prior work has demonstrated heightened cough response to capsaicin in patients with mild to moderate asthma, providing evidence of neuronal dysfunction in this disease [12]. Concerns about safety and tolerability of capsaicin challenge in the severe asthma population have been in part addressed by a small study suggesting that capsaicin challenge is safe and tolerable in this cohort [12,17]. Kanemitsu et al [18] are the first group to evaluate capsaicin cough sensitivity (C-CS) in the severe asthma population.…”

Section: Contextmentioning

confidence: 99%

Is there clinical value in performing capsaicin cough challenges in patients with severe asthma?

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Satia

2021

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Investigating the safety of capsaicin cough challenge in severe asthma

Cited by 14 publications

References 9 publications

Airways diseases: asthma, COPD and chronic cough highlights from the European Respiratory Society Annual Congress 2018

Airways diseases: asthma, COPD and chronic cough highlights from the European Respiratory Society Annual Congress 2018

Comparative effects of capsaicin in chronic obstructive pulmonary disease and asthma (Review)

Is there clinical value in performing capsaicin cough challenges in patients with severe asthma?

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