Investigating the Seroprevalence of Hepatitis E Among Blood Donors Referring to Blood Donation Centers in Birjand County in Iran

Azarkar, Zohreh; Miri, Mohammad Reza; Arjmand, Shima

doi:10.17795/modernc.9456

Cited by 4 publications

(4 citation statements)

References 15 publications

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“…Results of this study showed that a positive serology of HEV was lower in educated people, which conforms to the results of the previous studies in Iran (6,8,10). Positive serology in people with primary education was 3.87 compared to people with an academic education.…”

Section: Discussionsupporting

confidence: 92%

“…In the majority of the studies, no relation was established between age and prevalence of the disease, which is similar to the current study (3,6,8,10). Results of this study showed that a positive serology of HEV was lower in educated people, which conforms to the results of the previous studies in Iran (6,8,10).…”

Section: Discussionsupporting

confidence: 87%

“…As it is endemic, hepatitis E can be the reason for high incidence of the disease in the eastern region of the country (8).…”

Section: Discussionmentioning

confidence: 99%

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Seroprevalence and Risk Factors of Hepatitis E in Eastern Iran

Azarkar

Ebrahimzadeh

Sharifzadeh

et al. 2017

Iran Red Crescent Med J

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Background: Hepatitis E infection is one of the most common causes of acute hepatitis. It is caused by the RNA virus of the hepatomegaly viridae family, which is transferred through stool in contaminated water. Cases of infection are most prevalent in developing countries. Objectives: This study was conducted to investigate the seroprevalence of hepatitis E among urban adults. The reason was the current lack of information on the hepatitis E prevalence among the general population in the city of Birjand in eastern Iran. This information is necessary because Southern Khorasan is in close proximity to Afghanistan. Methods: In this cross sectional study, 522 participants aged over 17 years were selected from the city of Birjand, eastern Iran, using the random cluster sampling. The participants completed a researcher-made questionnaire that included demographic characteristics, risk factors for infectious diseases such as records of blood transfusions, specific exposures, intravenous drug abuse, recent diagnosis or a history of liver disease, and other medical information. After selection, a blood sample was taken from each participant to a volume of 5 cc. Each blood sample was then measured for the title of IgG antivirus of hepatitis E by the enzyme-linked immunosorbent assay (ELISA) method using the third generation ELISA kit made by Delavara Company.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 87%

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Seroprevalence and Risk Factors of Hepatitis E in Eastern Iran

Azarkar

Ebrahimzadeh

Sharifzadeh

et al. 2017

Iran Red Crescent Med J

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“…HEV-IgM was positive in 10 (5%) donors, and HEV-RNA was detected in 6 (3%) cases of the blood donors. The incidence of HEV viremia in European studies ranges from 1:600 to 1:15000 [28,34,35], and several studies have documented HEV blood transfusion transmission [34,36,37]. The genotype of HEV was genotype 1.…”

Section: Positive Heviggmentioning

confidence: 99%

Study of Hepatitis E Virus in Blood Donors

Al-Kasaby¹,

Zaki²

2019

TOMICROJ

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Introduction:Hepatitis E (HEV) is a major health problem affecting around one third of the world population. The prevalence of antibodies to HEV among blood donors have been documented in several countries in Europe and Asia. Objectives:The aims of the study are to estimate the seroprevalence of hepatitis E antibodies among healthy blood donors and to explore the factors associated with positive HEV antibodies among healthy blood donors. Moreover, to detect HEV viremia by real time polymerase chain reaction among seropositive blood donors for HEV. Methods:The study included 200 apparent healthy blood donors from Dakahlia Governorate, Egypt. Blood samples were collected from the blood donors for serological determination for specific hepatitis E virus immunoglobulin G (anti-HEV IgG) and specific hepatitis E virus immunoglobulin M (anti-HEV IgM). Positive samples for anti-HEV IgM were further subjected for determination of HEV-RNA by real time Polymerase Chain Reaction (PCR). Anti-HEV-IgG was positive in 50 donor (25%) anti-HEV-IgM was positive in 10 donors (5%) and HEV-RNA was positive in 6 donors (3%). Results and Discussion:The comparison between blood donors positive for anti-HEV-IgG and negative blood donors negative reveals significant association between anti-HEV-IgG and donors with older age (42.0 ± 9.7,P = 0.001),rural residence (76%, P = 0.001), workers in agricultural works (92%, P = 0.035) and elevated AST (31.28±14.28, P = 0.04). Regarding viral markers, there was significant prevalance between positive anti-HCV-IgG and positive anti-HEV-IgG (P = 0.003). Univariate analysis for risk factors associated with positive anti-HEV IgG reveals significant prevalence with older age (P = 0.001), rural residence (P < 0.001), positive anti-HCV-IgG (P = 0.004) and increase in AST (P = 0.045). However, on Multivariate analysis HEV infection was independently prevalent with older age (P < 0.001) and rural residence (P = 0.002). Conclusion:The present study highlights that HEV seroprevalence in blood donors is common finding. Further finding is the statistically significant correlation between antibodies to HCV and serological markers for HEV and even HEV viremia. Longitudinal studies may be needed to explore the clinical significance and cost effectiveness of screening of the blood donors for hepatitis E virus by serological tests and/or detection of viremia by Molecular testing.

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Seroprevalence of Hepatitis E Virus Infection in Middle Eastern Countries: A Systematic Review and Meta-Analysis

Qashqari

2022

Medicina

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Hepatitis E virus (HEV) is a hepatotropic virus that is a major public health concern worldwide. Autochthonous HEV is spread through oral feces in unsanitary environments, as well as vertical and, occasionally, blood transfusion. HEV is more common in developing countries, but it has recently become more widespread in developed countries as well. The Middle East (ME) has long been an endemic location for HEV infection. Therefore, the aim of this systematic review and meta-analysis was to assess the seroprevalence of anti-HEV antibodies in ME countries. The author systematically searched five databases, namely ScienceDirect, EMBASE, Scopus, PubMed, and Google Scholar, to identify English-language articles published on or before 25 April 2022. Comprehensive meta-analysis software was used for all statistical analyses (CMA, version 3, BioStat, Englewood, CO, USA). After quality control and exclusion of irrelevant studies, 80 studies were included in the qualitative synthesis and meta-analysis. A forest plot showed that the overall pooled seroprevalence of HEV infection in ME countries in the fixed-effect and random-effect models were 21.3% (95% CI: 0.209–0.216) and 11.8% (95% CI: 0.099–0.144), respectively. Furthermore, the findings showed a high level of heterogeneity (I2 = 98.733%) among the included studies. In both fixed-effect and random-effect models, the seroprevalence of HEV infection by country was high in Egypt as compared to other regions, at 35.0% (95% CI: 0.342–0.359), and 34.7% (95% CI: 0.153–0.611), respectively. The seroprevalence of HEV infection by country was high among pregnant women, at 47.9% (95% CI: 0.459–0.499) in the fixed-effect model, and in renal transplant recipients, at 30.8% (95% CI: 0.222–0.410) in the random-effect model. The seroprevalence of HEV infection varies by country and study population in the Middle East. More research is needed to determine the disease’s incidence, morbidity, and mortality in the region, where it is prevalent.

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Investigating the Seroprevalence of Hepatitis E Among Blood Donors Referring to Blood Donation Centers in Birjand County in Iran

Cited by 4 publications

References 15 publications

Seroprevalence and Risk Factors of Hepatitis E in Eastern Iran

Seroprevalence and Risk Factors of Hepatitis E in Eastern Iran

Study of Hepatitis E Virus in Blood Donors

Seroprevalence of Hepatitis E Virus Infection in Middle Eastern Countries: A Systematic Review and Meta-Analysis

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