Investigating the stability of gold nanorods modified with thiol molecules for biosensing

Gong, Yongxiang; Liu, Jian; Liu, Runcong; Wang, Jiaojiao; Niu, Chunmei; Zhu, Wenfeng; Xu, Dongmei; Hu, Zhongbo; Li, Min; Zhao, Yuliang

doi:10.1039/c5ra22133a

Cited by 2 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The maximum absorption wavelength at 800–840 nm represents the aspect ratio of AuNR, formed as 4.0–4.2. [ 24,25 ] The TEM image of MHA‐AuNR shows that a homogeneous nanorod structure was fabricated. The particle length and width were, respectively, 38 ± 2.9 nm and 9.3 ± 0.7 nm (Figure 2B).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Fabrication of gold nanohybrids modified with antibody and functional dendrimers for targeted photothermal theranostics

et al. 2020

View full text Add to dashboard Cite

Targeted theranostics can improve benefits of therapeutics or imaging probes by minimizing the dose and by selective delivery to a target site. For this study, a gold nanorod (AuNR)‐based nanohybrid was designed for efficient cancer treatment and diagnosis. The AuNR was functionalized with polyamidoamine dendrimers having poly(ethylene glycol) and Gd‐DOTA residues to provide biocompatibility and magnetic resonance (MR) imaging properties. Furthermore, trastuzumab was conjugated to the obtained nanohybrids to enhance the delivery performance to HER2‐expressing tumor cells. Fabricated nanohybrids possessed uniform hydrodynamic diameter and showed typical surface plasmon absorption, which is useful to convert light energy to heat for photothermal therapy. Nanohybrids exhibited T1‐weighted relaxation and comparable MR imaging property to that of commercially available MR contrast reagent. In vitro experiments demonstrated that photothermal effects of nanohybrid under near infrared (NIR) irradiation were sufficient to kill 80%–90% of cancer cells. The combination of the targeted nanohybrid and NIR laser irradiation strongly suppressed tumor growth and extended the survival of HER2‐positive SKOV3 tumor‐bearing nude mice. Therefore, fabricated nanohybrids are promising for targeted photothermal therapy and imaging.

show abstract

Section: Resultsmentioning

confidence: 99%

“…The AuNR concentrations of 5–200 µg mL −1 exhibited no significant change in cell viability against SKOV3 cells after 4 hours incubation, indicating that the MHA‐AuNR and nanohybrids have no readily apparent cytotoxicity. [ 24,31 ]…”

Section: Resultsmentioning

confidence: 99%

Fabrication of gold nanohybrids modified with antibody and functional dendrimers for targeted photothermal theranostics

et al. 2020

View full text Add to dashboard Cite

show abstract

Gold nanorods vs. gold nanoparticles: application in electrochemical sensing of cytosine β-d-arabinoside using metal ion mediated molecularly imprinted polymer

2016

View full text Add to dashboard Cite

show abstract

Investigating the stability of gold nanorods modified with thiol molecules for biosensing

Abstract: Studying the stability of centrifugated gold nanorods unmodified/modified with thiols.

Cited by 2 publications

References 29 publications

Fabrication of gold nanohybrids modified with antibody and functional dendrimers for targeted photothermal theranostics

Fabrication of gold nanohybrids modified with antibody and functional dendrimers for targeted photothermal theranostics

Gold nanorods vs. gold nanoparticles: application in electrochemical sensing of cytosine β-d-arabinoside using metal ion mediated molecularly imprinted polymer

Contact Info

Product

Resources

About