Investigating the therapeutic potential of venom-derived compounds for the management of Alzheimer's disease: a comprehensive review

Abstract

Alzheimer’s disease is a comprehensive clinical syndrome featuring cognitive, emotional, and volitional function deterioration. Treatment strategies for Alzheimer's disease involve a mix of pharmacological and non-pharmacological approaches. Current treatments focus on palliative care with limited impact on the disease course. Venom-derived substances, known for their neuroactive properties, have emerged as a novel approach to Alzheimer's treatment. Our team conducted a thorough search for electronic literature related to therapeutic venom-derived substances efficacy in Alzheimer’s disease in different databases, including Medline, PubMed, Google Scholar, and Psych INFO, up to May 2024. In this article, the therapeutic effects of various venom-derived substances effects in Alzheimer’s disease are discussed. Various substances grant anti-inflammatory and anti-oxidant effects. The clinical application of venom-derived therapy is still a long way ahead, still, researchers believe that the ongoing work will eventually allow its compounds to be considered definitive candidates in various therapies in upcoming years.