2022
DOI: 10.3390/pr10030454
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Investigating the Trade-Off between Design and Operational Flexibility in Continuous Manufacturing of Pharmaceutical Tablets: A Case Study of the Fluid Bed Dryer

Abstract: Market globalisation, shortened patent lifetimes and the ongoing shift towards personalised medicines exert unprecedented pressure on the pharmaceutical industry. In the push for continuous pharmaceutical manufacturing, processes need to be shown to be agile and robust enough to handle variations with respect to product demands and operating conditions. In this paper we examine the use of operational envelopes to study the trade-off between the design and operational flexibility of the fluid bed dryer at the h… Show more

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Cited by 4 publications
(1 citation statement)
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“…The contribution by David Bogle et al [1] addresses the present and future situation of the high complexity inherent with batch manufacturing of many products. The intrinsic flexibility associated with batch manufacturing has been the choice of most pharma products manufacturing.…”
Section: Original Researchmentioning
confidence: 99%
“…The contribution by David Bogle et al [1] addresses the present and future situation of the high complexity inherent with batch manufacturing of many products. The intrinsic flexibility associated with batch manufacturing has been the choice of most pharma products manufacturing.…”
Section: Original Researchmentioning
confidence: 99%