This paper identifies and classifies the essential constraints that must be addressed to allow U-space traffic autonomous guidance. Based on an extensive analysis of the state of the art in robotic guidance, physics of flight, flight safety, communication and navigation, uncrewed aircraft missions, artificial intelligence (AI), social expectations in Europe on drones, etc., we analyzed the existing constraints and the information needs that are of essential importance to address the identified constraints. We compared the identified information needs with the last edition of the U-space Concept of Operations and identified critical gaps between the needs and proposed services. A high-level methodology to identify, measure, and close the gaps is proposed.