Investigating the validation of the Chinese Mandarin version of the Social Responsiveness Scale in a Mainland China child population

Cen, Chaoqun; Liang, Yayong; Chen, Qiuru; Chen, Kaiyun; Deng, Hong-zhu; Chen, Bi-yuan; Zou, Xiaobing

doi:10.1186/s12888-016-1185-y

Cited by 95 publications

(65 citation statements)

References 48 publications

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“…These results are consistent with the findings in previous studies based on UK and Japanese samples [Auyeung et al, 2008;Wakabayashi et al, 2007]. Similar results were also reported in study using other instruments, for instance, the SRS [Cen et al, 2017]. A significant and positive correlation was found between the scores of the Chinese-AQ-Girls and age.…”

Section: Discussionsupporting

confidence: 93%

“…Each item is rated on 4‐point Likert scale, with total scores ranging from 0 to 195 (the higher score indicating more autistic traits). A previous study has found that the reliability and validity for Mandarin Chinese version of SRS were satisfactory to good (Cronbach's α = 0.89), supporting it as a reliable instrument for children in mainland China [Cen et al, ].…”

Section: Methodsmentioning

confidence: 97%

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Psychometric properties of the chinese version of autism spectrum quotient‐children's version: A sex‐specific analysis

et al. 2018

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A Simplified Chinese translation of the Autism Spectrum Quotient‐Children's Version (AQ‐C) is needed for research in mainland China. Autism Spectrum Disorder (ASD) is a condition that differs in presentation and prevalence by sex. Thus, evaluating the psychometric validity of the AQ‐C in males and females is an important step in its validation. The present study aims to develop a Chinese translation of the parent‐report AQ‐C, and test its psychometric properties among Mandarin Chinese speaking boys and girls. A total of 1,020 non‐clinical children and 134 children with ASD were assessed. Factor analyses were performed for the whole sample, as well as for girls and boys separately. A 30‐item, 5‐factor model (the Chinese AQ‐C) showed adequate goodness of fit (root mean square error of approximation [RMSEA] = 0.037; comparative fit index [CFI] = 0.907; Tucker‐Lewis index [TLI] = 0.901) for the whole sample. According to parents' reports, non‐clinical boys had significantly higher scores than non‐clinical girls on the Chinese AQ‐C. Sex‐specific factor structures were identified resulting in a 4‐factor model with 32 items for girls (the Chinese AQ‐Girls), and a 4‐factor model with 34 items for boys (the Chinese AQ‐Boys). The cut‐off scores of the Chinese AQ‐C, AQ‐Girls, and AQ‐Boys were 44.5, 42.5, and 46.5, respectively. These three Chinese versions of the AQ‐C all showed satisfactory internal consistency (α = 0.786–0.840) and concurrent validity with the Social Responsiveness Scale (r = 0.789–0.814) for the total scale. Differences have been found in the sex‐specific factor structures of the AQ‐C which would be more reliable to use for future research when measuring autistic traits in the general population. Autism Res 2019, 12: 303–315 © 2018 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary This study developed Chinese versions of the Autism Spectrum Quotient‐Children's Version (AQ‐C) in Chinese boys and girls together and separately. The AQ‐C showed good psychometric properties in boys and girls together and separately. There were differences in sex‐specific factor structures of the AQ‐C. These results suggest that the sex‐specific Chinese versions of the AQ‐C provide reliable and valid measurement of autistic traits.

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Section: Discussionsupporting

confidence: 93%

Section: Methodsmentioning

confidence: 97%

Psychometric properties of the chinese version of autism spectrum quotient‐children's version: A sex‐specific analysis

et al. 2018

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“…Symptoms of the children with ASD were assessed with the Autism Behavior Checklist (ABC) [14], Social Responsiveness Scale (SRS) [15]and the CARS test. Higher scores of ABC, CARS, and SRS scores indicate more serious autistic symptoms.…”

Section: Subjectsmentioning

confidence: 99%

Alterations in Gut Vitamins and Amino Acids Metabolism are Associated with Symptoms and Neurodevelopment of Children with Autism Spectrum Disorders

Zhu

Hua

Yang

et al. 2020

Preprint

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Background Accumulated evidence have supported metabolic disturbance may be associated with the pathogenesis of autism spectrum disorders (ASD). Despite abnormalities of some shared metabolic pathways, specific differential compounds are inconsistent in studies, which made a challenge to elucidate the role of metabolism in the mechanism of ASD. Besides, few researches have assessed the correlation between gut metabolites with symptoms of ASD. Objectives The present study aimed to evaluate the gut metabolomic profiles of children with ASD and to analyze potential interaction between gut metabolites with symptoms and neurodevelopment of ASD children. Methods In this cross-sectional case-control study, 120 aged 2–6 years ASD children and 60 sex and age matched typically developing (TD) children were included. Autistic symptoms were assessed with the Autism Behavior Checklist (ABC), Childhood Autism Rating Scale (CARS), and the Social Responsiveness Scale (SRS). Neurodevelopment was assessed with the Gesell Developmental Scale (GDS). Fecal samples were analyzed by untargeted liquid chromatography-mass spectrometry (LC-MS) methods, then systematic bioinformatic analyses were performed to characterize the gut metabolomic profiles of ASD and TD children. The correlations between metabolites and clinical assessment scores were assessed using Spearman correlation. Results ASD children exhibit gut metabolism perturbation compared with TD children. A total of 96 differential metabolites between the ASD and TD groups were identified, with 35 increased and 61 decreased in ASD group. The metabolic disturbance of ASD involved in multiple vitamins and amino acids metabolism pathways, with the strongest enrichment identified for tryptophan metabolism, retinol metabolism, cysteine and methionine metabolism, and vitamin digestion and absorption. The imbalanced gut metabolites are significantly correlated to symptoms and neurodevelopment of ASD children. Limitations This cross-sectional study revealed a correlation, but do not allow to prove causation of symptoms and gut metabolites outcome. The disease specificity of the metabolomic disturbance need to be evaluated in future studies.Conclusions ASD children have altered gut metabolite profiles compared with TD children, which mainly involved in multiple vitamins and amino acids metabolism pathways. Notably, vitamins metabolism abnormalities may play roles in the disturbance of amino acids metabolism. Imbalanced gut metabolites are related to symptoms and neurodevelopment of ASD children. Our findings provided an improved understanding of perturbations of metabolome networks in ASD.

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“…Subjects aged 4 to 10 years in the dataset were selected. The Social Responsiveness Scale (SRS) was used as a complementary diagnostic test in the study, and a total raw score of 56.5 was set as the cutoff score [22]. Subjects who scored above 56.5 in the control group and scored below 56.5 in the case group were excluded.…”

Section: Subjectsmentioning

confidence: 99%

The association of sleep problems in children with autism and parental quality of life

Liu

Dong

Wang

et al. 2020

Preprint

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Background Many children with autism suffer from sleep problems that impact not only children’s daytime behavior and cognitive development but also their parents’ life and health. The current study explored how and to what extent sleep problems in children with autism spectrum disorder (ASD) impacted their parents’ quality of life (QOL). Methods This study adopted a case-control study design. A total of 440 ASD children aged 4 to 10 years and 344 age-matched typically developing (TD) children were included in the study. The Children’s Sleep Habits Questionnaire (CSHQ) was used to measure sleep problems in the enrolled children, and parental QOL was measured by the Short Form 36 Health Survey Questionnaire Version 2.0 (SF-36v2). Linear regression and pathway analysis were used to explore the impact of children’s sleep problems on parental QOL. Results The linear regression model showed that the CSHQ total scores were negatively associated with maternal mental health summary (MCS) scores (β=-2.831, p=0.005) in the TD group. In the ASD group, the CSHQ total scores were negatively associated with the parental physical health summary (PCS) scores (β=-3.030, p=0.003 for mothers, β=-3.651, p<0.001 for fathers) after adjusting for the child’s age, parental age, parental Zarit Caregiver Burden Interview (ZBI) score and Social Responsiveness Scale (SRS) score as covariates. The pathway analysis indicated that sleep problems in ASD children had both direct and indirect effects on maternal PCS. Conclusion The main results of the current study showed that sleep problems in children with or without ASD may affect parental QOL in different ways, and ASD children’s sleep problems affect parental physical health as a risk factor independent from the social impairments associated with ASD and the childcare burden of the parents.

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Investigating the validation of the Chinese Mandarin version of the Social Responsiveness Scale in a Mainland China child population

Cited by 95 publications

References 48 publications

Psychometric properties of the chinese version of autism spectrum quotient‐children's version: A sex‐specific analysis

Psychometric properties of the chinese version of autism spectrum quotient‐children's version: A sex‐specific analysis

Alterations in Gut Vitamins and Amino Acids Metabolism are Associated with Symptoms and Neurodevelopment of Children with Autism Spectrum Disorders

The association of sleep problems in children with autism and parental quality of life

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