Investigating the Vinblastine Induced-Chromosomal Abnormality in the Already Gamma Irradiated L929 Cell Line Using Micronucleus Assay in Cytokinesis Blocked Binucleated Cells

Abstract

Aneuploidy, by unbalancing the expression of several genes, induces tumor formation through disturbing the cell equilibrium. Damages to the cells normal status, in turn, induce more abnormal chromosome segregation during cell divisions (Passerini and Storchova, 2016). The relationship between aneuploidy and cancer is so strong that it is suggested to be used as a biomarker for integrated chemical assessments of carcinogenicity (Mandrioli et al.,