Investigating therapeutic usage of combined Ticagrelor and Aspirin through solid-state and analytical studies

Yayé, Hassane Sadou; Rietveld, Ivo B.; Secrétan, Philippe-Henri; Faucheron, Antoine; Karoui, Maher; Tilleul, P.; Yagoubi, Najet; Do, Bernard

doi:10.1016/j.ejps.2017.06.031

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…Ticagrolol (TIC) (Figure 1) is a new antiplatelet therapy in patients with ACS or prior myocardial infarction with a favorable safety profile [1][2][3]. TIC was approved for use in both the USA and the European Union in combination with aspirin, as an antiplatelet therapy in patients with ACS and in those undergoing percutaneous coronary intervention [4,5].…”

Section: Introductionmentioning

confidence: 99%

Determination of ticagrelol in rat plasma and tablets by micellar electrokinetic chromatography coupled with large volume sample stacking: Application to a pharmacokinetic study

Zayed,

Belal

2023

J of Separation Science

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A method using micellar electrokinetic chromatography coupled with large‐volume sample stacking for the determination of ticagrelol was developed and validated. The analysis was performed in a fused silica capillary (41.5 cm effective length, 50 μm diameter) with ultraviolet detection at 195 nm. The background electrolytes were 30 mM phosphate buffer of pH 3.0 with 120 mM sodium dodecylsulfate and 10 % (v/v) acetonitrile (120 s X 50 mbar; 20°C; ‐18 kV) and 30 mM borate buffer of pH 8.5 with 75 mM sodium dodecylsulfate (120 s X 50 mbar; 20°C; 25 kV); under acidic and alkaline conditions, respectively. The method was found to be reliable with respect to specificity, linearity of the calibration line (R2 > 0.99), repeatability (relative standard deviation 2.56%–3.34%), and accuracy (recovery in the range 101.21%–102.67%). The limits of detection and quantitation were 0.032, 0.071, and 0.087, 0.188 μg/mL, respectively. The method was successfully applied for the determination of ticagrelol concentrations in rat plasma and tablets with good recoveries and reproducibility. The presented method proved to be suitable for monitoring ticagrelor in rat plasma .

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Section: Introductionmentioning

confidence: 99%

Determination of ticagrelol in rat plasma and tablets by micellar electrokinetic chromatography coupled with large volume sample stacking: Application to a pharmacokinetic study

Zayed,

Belal

2023

J of Separation Science

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Analytical methodologies for the determination of ticagrelor

Kelemen

Hancu

Papp

2019

Biomedical Chromatography

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Ticagrelor is an orally administered platelet aggregation inhibitor with a cyclopentyl‐triazolopyrimidine structure; it is a selective reversible P2Y12 receptor antagonist, which prevents P2Y12‐mediated and ADP‐mediated platelet activation and aggregation. It is used to reduce the rate of cardiovascular death, myocardial infarction and stroke in patients with acute coronary syndrome or history of myocardial infarction. Several analytical methods have been published for the determination of ticagrelor in pharmaceuticals and biological materials by spectrophotometry, high‐performance liquid chromatography with ultraviolet detection and liquid chromatography coupled with tandem mass spectrometry. The purpose of the current review is to provide a systematic survey of the analytical techniques used for the determination of ticagrelor since its introduction in therapy until today.

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Ticagrelor

Kabil¹,

Dena

El‐Sherbiny³

2022

Profiles of Drug Substances, Excipients and Related Methodology

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Investigating therapeutic usage of combined Ticagrelor and Aspirin through solid-state and analytical studies

Abstract: ABSTRACT:The mainstay treatment for patients with acute coronary syndrome is an oral route dual antiplatelet therapy with a P2Y12-receptor antagonist and Aspirin (ASA).To improve patient adherence to such treatments, combination therapies (polypill) are envisioned.

Cited by 4 publications

References 33 publications

Determination of ticagrelol in rat plasma and tablets by micellar electrokinetic chromatography coupled with large volume sample stacking: Application to a pharmacokinetic study

Determination of ticagrelol in rat plasma and tablets by micellar electrokinetic chromatography coupled with large volume sample stacking: Application to a pharmacokinetic study

Analytical methodologies for the determination of ticagrelor

Ticagrelor

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