The relationship between humans and wild animals is an ancient problem which is increasing due to the fast population growth, constructing roads, bridges, and invading the natural habitats of these animals. Problems like this are more evident when association of disease with wildlife occurs, such as the case of yellow fever in tropical countries. Primates are sensitive to yellow fever and they are suffering from human violence due to the lack of information about this disease, i.e., primates are being killed by humans because humans think that primates could be spreading the disease. However, primates do not present this condition. Then, the aim this work is to comment about the relation human-wildlife (primates, in specific) in relation to yellow fever. In short, to preserve the wildlife and, mainly, primates, actions from society and government should be implemented to provide information about yellow fever and to preserve primates.