Investigation and analysis of oncologists&amp;#39; knowledge of morphine usage in cancer pain treatment

Liu, Weiran; Xie, Shusen; Lin, Yongcheng; Woo, Stephanie; Li, Weilin; Miller, Adam; Huang, Lijun; Zhang, Lei

doi:10.2147/ott.s61033

Cited by 3 publications

(1 citation statement)

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“…Mice which had a latency time from 5 to 20 s were sorted out. The selected 40 mice were divided into four treatment groups as conducted in the acetic acid-induced writhing test except for PG in which mice received gavage with bucinnazine (15 mg/kg), an analgesic drug [ 19 ]. The experiment lasted for 7 days.…”

Section: Methodsmentioning

confidence: 99%

Study of analgesic effect of earthworm extract

Luo

Deng

et al. 2018

Bioscience Reports

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Pain represents a major clinical problem and one which has exercised generations of healthcare professionals. Earthworms are used as a traditional Chinese medicine, and have been applied pharmacologically and clinically since a long time in China. However, the analgesic effects of earthworm extract (EE) are seldom studied. Hence, we evaluated the analgesic effects of EE in mice. The obtained data showed that EE increased pain threshold and exhibited peripheral but not central analgesic effects in mice; evidenced by increased inhibition ratio in acetic acid writhing test and formalin test, whereas only slight increase in inhibition ratio in hot plate test and tail immersion test. In addition, EE decreased serum norepinephrine (NE), 5-hydroxytryptamine (5-HT), and nitric oxide (NO) synthase (NOS) concentration, similar to other analgesic drugs like morphine and aspirin. In a nutshell, the obtained data have demonstrated that EE has peripheral analgesic properties and could be used as a promising analgesic drug.

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Section: Methodsmentioning

confidence: 99%

Study of analgesic effect of earthworm extract

Luo

Deng

et al. 2018

Bioscience Reports

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A survey of perceptions, attitudes, knowledge and practices of medical oncologists about cancer pain management in Spain

et al. 2018

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The Status and Prescription Patterns of Opioid Utilization in a Large Comprehensive Teaching Hospital in China According to the Anatomical Therapeutic Chemical Classification/Defined Daily Dose Methodology

Fang

Zhang²,

Wu³

et al. 2022

Front. Psychiatry

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BackgroundFew studies have analyzed opioid consumption and the average daily dose and duration for different patients in hospital settings in China. The aim of this study was to measure the status of and trends in prescribed opioids and the prescribing patterns at the Second Xiangya Hospital.MethodsThe data were obtained from the prescribed medicine database of the inpatient department. We included patients who were >18 years old and received any level of opioid analgesic between 2012 and 2017. The international Anatomical Therapeutic Chemical Classification/Defined Daily Dose (ATC/DDD) methodology was used to standardize the consumption rates. All opioid units were converted into morphine equivalents (MEs) to analyze the specific opioid usage.ResultsThe consumption of prescribed opioids increased from 3.16 to 3.74 DDD/100 bed-days (+18.3%) from 2012 to 2017. Both cancer and noncancer patients had similar administration routes and median daily dosages in MEs, but cancer patients had longer treatment durations (median: 5 days vs. 1 day, respectively). The median average daily dose and treatment duration for all patients were 15 MEs/day and 2 days, respectively, for oral administration, 100 MEs/day and 1 day for parenteral administration, and 47.14 MEs/day and 5 days for both oral and parenteral administration.ConclusionAlthough there was a tendency toward an increase in opioid consumption, the overall level of consumption in the Second Xiangya Hospital remained relatively low. Thus, it is urgently necessary to increase the availability of opioids and alter prescription habits for them in order adopt the current concept of pain management developed by the World Health Organization (WHO).

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Investigation and analysis of oncologists' knowledge of morphine usage in cancer pain treatment

Cited by 3 publications

References 20 publications

Study of analgesic effect of earthworm extract

Study of analgesic effect of earthworm extract

A survey of perceptions, attitudes, knowledge and practices of medical oncologists about cancer pain management in Spain

The Status and Prescription Patterns of Opioid Utilization in a Large Comprehensive Teaching Hospital in China According to the Anatomical Therapeutic Chemical Classification/Defined Daily Dose Methodology

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