Investigation and Characterization of Factors Affecting Rheological Properties of Poloxamer-Based Thermo-Sensitive Hydrogel

Chen, I-Cheng; Su, Chen‐Ying; Chen, Pei-Yu; Hoang, The Chien; Tsou, Yi-Syue; Fang, Hsu‐Wei

doi:10.3390/polym14245353

Cited by 17 publications

(7 citation statements)

References 64 publications

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“…In the future, injectable poloxamer hydrogels are expected to remain an exciting research topic not only for drug delivery but also for tissue engineering [100] and cartilage repair [101,102]. Regarding local cancer therapy, one can envision phototherapy and immunotherapy succeeding chemotherapy as the most applied therapeutic modalities, with increasingly frequent reports.…”

Section: Discussionmentioning

confidence: 99%

Injectable Poloxamer Hydrogels for Local Cancer Therapy

Marques

Costa

Velho

et al. 2023

Gels

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The widespread push to invest in local cancer therapies comes from the need to overcome the limitations of systemic treatment options. In contrast to intravenous administration, local treatments using intratumoral or peritumoral injections are independent of tumor vasculature and allow high concentrations of therapeutic agents to reach the tumor site with minimal systemic toxicity. Injectable biodegradable hydrogels offer a clear advantage over other delivery systems because the former requires no surgical procedures and promotes drug retention at the tumor site. More precisely, in situ gelling systems based on poloxamers have garnered considerable attention due to their thermoresponsive behavior, biocompatibility, ease of preparation, and possible incorporation of different anticancer agents. Therefore, this review focuses on the use of injectable thermoresponsive hydrogels based on poloxamers and their physicochemical and biological characterization. It also includes a summary of these hydrogel applications in local cancer therapies using chemotherapy, phototherapy, immunotherapy, and gene therapy.

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Section: Discussionmentioning

confidence: 99%

Injectable Poloxamer Hydrogels for Local Cancer Therapy

Marques

Costa

Velho

et al. 2023

Gels

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“…Stability testing is an important assay in the quality control of a pharmaceutical product, since it produces evidence on how various environmental factors (e.g., temperature, humidity, and light) can influence and, consequently, determine variations in the quality of a pharmaceutical preparation over time [ 55 ]. In the case of complex pharmaceutical semisolids containing multiple phases, such as polymeric-micelle-based hydrogels, increased temperature can modify their phase transitions (gelling behavior), micelle formation process, and phase distribution [ 56 ]. Furthermore, the long-term stability study of topical products based on nanocarriers, including polymeric micelles, loaded with essential oils provides evidence on carrier effectiveness to protect the volatile compounds from degradation and evaporation under the influence of temperature, light, and/or air.…”

Section: Discussionmentioning

confidence: 99%

Stability Profile and Clinical Evaluation of an Innovative Hydrogel Containing Polymeric Micelles as Drug Delivery Systems with Oregano Essential Oil against Fibroepithelial Polyps

et al. 2023

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Skin tags, also known as fibroepithelial polyps (FPs) or acrochordons, are soft, pigmented excrescences, with a prevalence of 50–60% in the population, occurring especially in the fourth decade of life. To date, FPs have been efficiently eliminated using minimum invasive methods such as surgical removal, cauterization, laser irradiation, and cryosurgery. Over-the-counter treatments are also of interest for patients due to their non-invasive character, but their clinical efficiency has not been clearly demonstrated. This study was designed in order to evaluate the efficacy of a modern-pharmaceutical-formulation-type poloxamer-based binary hydrogel, having Origanum vulgare L. essential oil (OEO-PbH) as an active ingredient in the management of FPs. The formulation has been shown to possess good qualities in terms of stability and sterility. Non-invasive measurements revealed changes in some physiological skin parameters. An increase in transepidermal water loss (TEWL) and erythema index was noted, while skin surface water content (SWC) decreased during eight weeks of treatment. The macroscopic evaluation revealed that the FPs dried and shrunk after topical treatment with OEO-PbH. Clinically, patients presented a lowering of the number of lesions on the treated area of 20–30% after one month of treatment and around 50% after the second month. Histopathological examination suggests that topical treatment with OEO-PbH may induce histological changes in the epidermis, dermis, and fibrovascular cores of FPs, including a loss of thickness, reduced size and number of blood vessels, and low cellularity. These changes may contribute to the observed reduction in size of FPs after treatment with OEO-PbH.

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“…Therefore, the T sol-gel of sHG-PF127 can be explained by the increase in polymer weight fraction arising from water evaporation during autoclaving. Nevertheless, since both T sol-gel values are too low for physiological applications, the combination of PF127 with Poloxamer 188 is recommended [41].…”

Section: Sol-gel Transitionmentioning

confidence: 99%

Effects of Steam Sterilization on the Properties of Stimuli-Responsive Polymer-Based Hydrogels

Ferreira

Marques

Costa

et al. 2023

Gels

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Hydrogels based on stimuli-responsive polymers can change their characteristics in response to small variations in environmental conditions, such as temperature, pH, and ionic strength, among others. In the case of some routes of administration, such as ophthalmic and parenteral, the formulations must meet specific requirements, namely sterility. Therefore, it is essential to study the effect of the sterilization method on the integrity of smart gel systems. Thus, this work aimed to study the effect of steam sterilization (121 °C, 15 min) on the properties of hydrogels based on the following stimuli-responsive polymers: Carbopol® 940, Pluronic® F-127, and sodium alginate. The properties of the prepared hydrogels—pH, texture, rheological behavior, and sol-gel phase transition—were evaluated to compare and identify the differences between sterilized and non-sterilized hydrogels. The influence of steam sterilization on physicochemical stability was also investigated by Fourier-transform infrared spectroscopy and differential scanning calorimetry. The results of this study showed that the Carbopol® 940 hydrogel was the one that suffered fewer changes in the studied properties after sterilization. By contrast, sterilization was found to cause slight changes in the Pluronic® F-127 hydrogel regarding gelation temperature/time, as well as a considerable decrease in the viscosity of the sodium alginate hydrogel. There were no considerable differences in the chemical and physical characteristics of the hydrogels after steam sterilization. It is possible to conclude that steam sterilization is suitable for Carbopol® 940 hydrogels. Contrarily, this technique does not seem adequate for the sterilization of alginate or Pluronic® F-127 hydrogels, as it could considerably alter their properties.

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Investigation and Characterization of Factors Affecting Rheological Properties of Poloxamer-Based Thermo-Sensitive Hydrogel

Cited by 17 publications

References 64 publications

Injectable Poloxamer Hydrogels for Local Cancer Therapy

Injectable Poloxamer Hydrogels for Local Cancer Therapy

Stability Profile and Clinical Evaluation of an Innovative Hydrogel Containing Polymeric Micelles as Drug Delivery Systems with Oregano Essential Oil against Fibroepithelial Polyps

Effects of Steam Sterilization on the Properties of Stimuli-Responsive Polymer-Based Hydrogels

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