Investigation and Identification of the Bromination Products of Dimethoxyamphetamines

Abstract

The qualitative analysis of the aromatic bromination products of the 6 isomeric dimethoxyamphetamines and their hydrochloride or hydrobromide salts is described. Their ultraviolet, mass, and proton magnetic resonance spectra are not sufficiently different for distinction but infrared spectra allow a positive identification to be made and reference spectra are provided for the bromination products of 2,4-, 2,5-, 2,6-, 4,5-, and 3,5-dimethoxyamphetamines. The application of gas-liquid and thin layer chromatography for the analysis of these products is discussed. The bromination of 2,3-dimethoxyamphetamine consistently gave mixtures which could not be separated satisfactorily; spectra are included for completeness of the comparison of products.

An Evaluation of the Potential for Clandestine Manufacture of 3,4-Methylenedioxyamphetamine (MDA) Analogs and Homologs

“…Safrole, isosafrole, and piperonal may themselves be prepared in good to excellent yields from 1,2-methylenedioxybenzene through the 4-bromo intermediate [106]. [112], ortho-safrole [113], 5.6-dimethoxysafrole [114], alkylenedioxy bridges [26,106,109,I10,I15,116], and brominated phenethylamine-based compounds [29,106,117]. Ring-substituted alpha methyl-3,4-methylenedioxyhydrocinnamic acids [74,75,80] may be prepared from appropriate aldehydes (three steps) and converted into methylenedioxyphenylisopropylamine analogs through the multi-step synthesis shown in Scheme 9 (Fig.…”