Investigation and Optimization of Formulation Parameters for Selfnanoemulsifying Delivery System of Two Lipophilic and Gastrointestinal Labile Drugs Using Box-Behnken Design

Abstract

Objective: Present research work aims toward codelivery of two hydrophobic drugs, curcumin (CRM) and duloxetine hydrochloride (DXH) through self-nanoemulsifying drug delivery systems (SNEDDS). Methods:Initially, binary mixture in the ratio of 1:1 was prepared and then loaded into SNEDDS. Box-Behnken design (BBD) was adopted to develop SNEDDS. As per the optimal design, 13 SNEDDS prototypes were prepared. Castor oil, tween-80 and Transcutol P ® were used as oil, surfactant, and cosurfactant, respectively. To 1 mL of SNEDDS, 30 mg each of CRM and DXH was loaded (CRM-DXH-SNEDDS). Results:The design revealed that for mean droplet size, polydispersity index (PDI), as well as percentage drug loading, all the three factors, i.e. ratio of oil (a), surfactant (b), and cosurfactant (c) were found to give significant effect. Factor B showed the most significant effect on mean droplet size (y1). In case of PDI (y2), factors B and C exerted maximum influence, whereas, Factor A has shown non-significant effect. For percentage drug loading of drugs (y3 and y4), all the three factors were found to have the most significant effect. The optimized batch of CRM-DXH-SNEDDS having composition castor oil, tween-80, and Transcutol P ® in the ratio: 2.17:5.22:2.61, revealed that the mean drug loading (%) of CRM and DXH in an optimized batch of SNEDDS was found to be 87.22±1.87 and 92.32±0.19%, respectively. The mean droplet size, PDI, and zeta potential of formed SNEDDS were observed as 113.14±1.14 nm, 0.20±0.026, and −13.2 mV, respectively. Conclusion:BBD provided optimal formula composition for SNEDDS for obtaining desirable drug loading, emulsion droplet size, and zeta potential.

Formulation of Nanostructured Lipid Carriers of Haloperidol Prepared by Using Clarified Butter

“…This means that the microemulsion of desired globular size with a smaller polydispersity index can be obtained and the preparation process can be successfully scaled up if sonication time as well as the amount of Smix added in the formulation, is properly controlled. This is the point of major concern as the clinical application of nanocarriers system is dependent on globular size and polydispersity index as key parameters [22][23][24]. The method used for the preparation of NLC was similar to that reported by Joshi and Patravale in 2006 with slight modifications.…”

Dissolution Enhancement of Tetrahydrocurcumin Using Optimized Self-Nanoemulsifying Drug Delivery System

“…Compared to the other curcuminoids, THC shows a stronger antioxidant and anti-inflammation activity [1]. The docking analysis showed that THC might be able to inhibit amyloid precursor protein (APP) so that it has the potential to be used in the treatment of Alzheimer's disease [2]. Although THC has potent activity, the bioavailability of THC is limited due to its poor water solubility and absorption.…”