Investigation and verification of the clinical significance and perspective of natural killer group 2 member D ligands in colon adenocarcinoma

Ruan, Guo‐Tian; Wang, Shuai; Zhu, Linghua; Liao, Xiwen; Wang, Xiangkun; Liao, Cun; Yan, Ling; Xie, Hailun; Gong, Yizhen; Gan, Jialiang; Gao, Feng

doi:10.18632/aging.202935

Cited by 5 publications

(3 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Their function in COAD diagnosis and prognosis was proved. Consistent with the findings of Li et al, previous researches suggested that ULBP2, SCIN , and KRT23 could be used as a diagnostic and prognostic biomarker of COAD in light of its high expression in the cancer tissues [ 14–16 ]. Besides, elevated level of SERPINA1 expression in serum samples of CRC patients was associated with disease progression [ 15 ].…”

supporting

confidence: 82%

Commentary on: Screening of immunosuppressive cells from colorectal adenocarcinoma and identification of prognostic markers

Chen

Zeng

et al. 2021

Bioscience Reports

View full text Add to dashboard Cite

Colorectal adenocarcinoma (COAD) is one subtype of colorectal carcinoma (CRC), whose development is associated with genetics, inappropriate immune response, and environmental factors. Although significant advances have been made in the treatment of COAD, the mortality rate remains high. It is a pressing need to explore novel therapeutic targets of COAD. Available evidence indicated that immune cell infiltration was correlated with cancer prognosis. To reveal the roles of immune cells in the COAD prognosis, a study published in Bioscience Reports by Li et al. (Bioscience Reports (2021) 41, https://doi.org/10.1042/BSR20203496) analyzed data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) dataset. It demonstrated a beneficial effect of Th17 cells in COAD prognosis. In addition, six hub genes (KRT23, ULBP2, ASRGL1, SERPINA1, SCIN, and SLC28A2) were identified to correlate with Th17 cells and COAD prognosis, suggesting one new therapy strategy and some predictive biomarkers of COAD. These findings reported by Li et al. may pave one way to explore the molecular mechanism of COAD further.

show abstract

supporting

confidence: 82%

Commentary on: Screening of immunosuppressive cells from colorectal adenocarcinoma and identification of prognostic markers

Chen

Zeng

et al. 2021

Bioscience Reports

View full text Add to dashboard Cite

show abstract

“…Moreover, high FGF5 expression was found to be significantly associated with poor overall survival and relapse-free survival in LUAD [ 39 ]. A report showed that RAET1L together with ULBP1, ULBP2, ULBP3 had the high diagnostic values in colon adenocarcinoma (COAD) [ 40 ]. AGER overexpression was found to suppress the cell proliferation, invasion and migration of H1299 cells [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of a Novel Immune-Related Gene Signature in Lung Adenocarcinoma

Feng

Liang

Shi

et al. 2022

JCM

View full text Add to dashboard Cite

Lung cancer is the major cause of cancer-related deaths around the world. Lung adenocarcinoma (LUAD), the most common subtype of lung cancer, contributed to the majority of mortalities and showed different clinical outcomes in prognosis. Tumor-infiltrated immune cells at the tumor site are associated with better survival and immunotherapy response. Thus, it is essential to further investigate the molecular mechanisms and new prognostic biomarkers of lung adenocarcinoma development and progression. In this study, a six-gene signature (CR2, FGF5, INSL4, RAET1L, AGER, and TNFRSF13C) was established to predict the prognosis of LUAD patients, as well as predictive value. The prognostic risk model was also significantly associated with the infiltration of immune cells in LUAD microenvironments. To sum up, a novel immune-related six-gene signature (CR2, FGF5, INSL4, RAET1L, AGER, and TNFRSF13C) was identified that could predict LUAD survival and is highly related to B cells and dendritic cells, which may provide a theoretical basis of personalized treatment for targeted immunotherapy.

show abstract

“…The expression of ULBP5 in patients without malignancy is generally low in healthy tissues. 25 The increase in ULBP5 can be caused by increased succinate, inhibition of fumarate hydratase activity, and decreased glutathione activity. Fumarate accumulation causes oxidative stress that triggers the expression of NKG2D ligands such as ULBP2 and ULBP5.…”

Section: Discussionmentioning

confidence: 99%

The mIRNA519a-3p and NKG2D in endometriosis.

Pramayadi

Natadisastra

Sumapradja

et al. 2022

Indones J Obstet Gynecol

View full text Add to dashboard Cite

Background: Natural killer (NK) cells play a role in pathogenesis of endometriosis. Lower expressions of NK cells receptor group 2D (NKG2D) ligands inhibits cytotoxic activity of NK cells; a common immunity avoidance mechanism in neoplasms. Literatures have proven miRNAs regulatory effect on NKG2D expression. There has been no specific biomarker for diagnosing endometriosis. Non-invasive means of diagnosing endometriosis may reduce well-known risks of invasive method of diagnosis and yield better results. Purpose: To investigate the correlation between miRNA-519a-3p expression with NKG2D ligands (MICA, MICB, ULBP 1-6) on endometriosis and non-endometriosis patients. Methods: This was a cross-sectional study held in five centers: dr. Cipto Mangunkusumo General Hospital, Pelni Hospital, Bunda Hospital, YPK Mandiri Hospital, and Primaya Evasari Hospital from October 2020 to July 2021. miRNA and NKG2DL analysis were done in Human Reproduction, Infertility and Family Planning (HRIFP) cluster at IMERI FKUI. Results: We obtained 19 patients in each study groups. NKG2D ligands and miRNA519a-3p relative expressions were not significantly different (p > 0.05). Increased miRNA519a-3p expression negatively affected NKG2D ligands expression. A decrease in ULBP1 and an increase in ULBP2 increased the probability for endometriosis. NKG2D ligands expression may be influenced by infection, pro-inflammatory cytokine production, dan polymorphism. NKG2D ligands expression level can be different depending on the origin of the sample. Lower expression of miRNA519a-3p indirectly inhibits tumor apoptosis by lowering NKG2D ligands, caspase, or mRNA. Conclussion: We did not manage to establish a correlation between NKG2D ligands with miRNA519a-3p in endometriosis and non-endometriosis patients.

show abstract

Investigation and verification of the clinical significance and perspective of natural killer group 2 member D ligands in colon adenocarcinoma

Cited by 5 publications

References 79 publications

Commentary on: Screening of immunosuppressive cells from colorectal adenocarcinoma and identification of prognostic markers

Commentary on: Screening of immunosuppressive cells from colorectal adenocarcinoma and identification of prognostic markers

Comprehensive Analysis of a Novel Immune-Related Gene Signature in Lung Adenocarcinoma

The mIRNA519a-3p and NKG2D in endometriosis.

Contact Info

Product

Resources

About