Investigation for the quality factors on the tablets containing medicated pellets

Tan, Xueying; Hu, Jingbo

doi:10.1016/j.jsps.2015.01.020

Cited by 13 publications

(6 citation statements)

References 29 publications

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“…A hardness test is the assessment of the force needed to fracture a tablet on its diameter [12]. Tablets are expected to be hard enough to remain whole during their removal from a blister pack.…”

Section: Discussionmentioning

confidence: 99%

“…For an active ingredient in a tablet to be available for absorption, such a tablet must first disintegrate and released the drug to the body fluids for dissolution. The disintegration of tablets yields drug particles with enlarged surface area for activity in the gastrointestinal tract [12]. The British Pharmacopoeia [14] specifies that uncoated tablets should disintegrate within 15 min.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Disintegration, Hardness and Dissolution Profiles of Paracetamol Tablets Formulated using Sucrose and Formaldehyde Cross-Linked Starches

Okeke

Oli

Yahaya

et al. 2021

JPRI

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Background: Native starches have some limitations such as the inability to withstand some processing conditions, poor flow, packing and compressibility. Cross-linking of starch is one of the methods used to overcome these drawbacks to obtain derivatives with better and desirable properties. This study is aimed at assessing the utilisabilty of sucrose and formaldehyde cross-linked starches obtained from Zea mays, Triticum aestivum, and Oriza sativa as an excipient for paracetamol tablet formulation. The formulated tablets were evaluated for hardness, disintegration and drug release rate. Results: The formulated tablets had hardness in the range of 4.35 – 6.37 Kgf. Tablets produced from the native starches had significantly (P < 0.05) lower disintegration time compared to their respective cross-linked starches. The disintegration time of the tablets from the cross-linked starches was in the following order, modified rice starch tablets > modified maize starch tablets > modified wheat starch tablets. The optimal batches containing the modified starches released over 90% of the drug within 40 min. Conclusion: Sucrose and formaldehyde cross-linked starches obtained from Zea mays, Triticum aestivum, and Oriza sativa could serve as possible excipients for paracetamol tablets formulation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Disintegration, Hardness and Dissolution Profiles of Paracetamol Tablets Formulated using Sucrose and Formaldehyde Cross-Linked Starches

Okeke

Oli

Yahaya

et al. 2021

JPRI

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“…First, MCC blank pellets were used as the pellet core. MCC with good tensile strength and elasticity coefficient (Tan & Hu, 2016) is considered as an ideal core material to afford the mechanical strength for the whole system. The DOXY-containing drug layer was then added, and the matrix of this layer was PVP K29/32 to provide an immediate-release behavior (Volkova, Perlovich, & Terekhova, 2017).…”

Section: Data Expression and Statisticsmentioning

confidence: 99%

Modified‐release oral pellets for duodenum delivery of doxycycline hyclate

Huang

et al. 2019

Drug Development Research

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To minimize the gastric and esophageal injury effect, a system to deliver doxycycline hyclate (DOXY) to the duodenum area is needed. DOXY‐containing modified‐release oral pellets (DMOP) coated with hydroxypropyl methylcellulose phthalate HP‐55 (HPMCP HP‐55) and hydroxypropyl methylcellulose E15 (HPMC E15) appear to be a reasonable choice. This coating layer dissolves at pH 5.5, which is the pH of the duodenum, but not at a gastric pH (1.2). The formulation and preparation of DMOP were optimized, and a scale‐up test was performed. The results showed that the production reproducibility was acceptable, and the quality of DMOP well met the standards of Chinese Pharmacopeia (Ch.P, 2015 edition). Notably, the accumulated DOXY release was lower than 50% at pH 1.2 (20 min) and higher than 85% at pH 5.5, which met the USP40‐NF35 standard for DOXY modified‐release formulations. Moreover, the storage stability of DMOP with different packages was investigated by stress testing, accelerated and long‐term testings. The stability of DMOP was maintained up to 12 months, in terms of DOXY content and in vitro release behavior. The results seem to suggest that DMOP could be a promising duodenum delivery system.

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“…Excipients incorporated within the pellet core along with the drug substance are mostly diluents (also referred to as fillers) and binders. Common excipients include MCC, PVP, hydroxypropyl methyl cellulose (HPMC), lactose, and starch [48]. A recent study conducted by Chin, Chan, and Heng suggested that the particle size of the lactose as a cushioning layer influenced the integrity of the compressed pellets.…”

Section: Coated Pellets (Reservoir-type Multiparticulate Drug Delimentioning

confidence: 99%

Oral Modified Release Multiple-Unit Particulate Systems: Compressed Pellets, Microparticles and Nanoparticles

et al. 2018

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Oral modified-release multiparticulate dosage forms, which are also referred to as oral multiple-unit particulate systems, are becoming increasingly popular for oral drug delivery applications. The compaction of polymer-coated multiparticulates into tablets to produce a sustained-release dosage form is preferred over hard gelatin capsules. Moreover, multiparticulate tablets are a promising solution to chronic conditions, patients’ adherence, and swallowing difficulties if incorporated into orodispersible matrices. Nonetheless, the compaction of multiparticulates often damages the functional polymer coat, which results in a rapid release of the drug substance and the subsequent loss of sustained-release properties. This review brings to the forefront key formulation variables that are likely to influence the compaction of coated multiparticulates into sustained-release tablets. It focusses on the tabletting of coated drug-loaded pellets, microparticles, and nanoparticles with a designated section on each. Furthermore, it explores the various approaches that are used to evaluate the compaction behaviour of particulate systems.

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Investigation for the quality factors on the tablets containing medicated pellets

Cited by 13 publications

References 29 publications

Disintegration, Hardness and Dissolution Profiles of Paracetamol Tablets Formulated using Sucrose and Formaldehyde Cross-Linked Starches

Disintegration, Hardness and Dissolution Profiles of Paracetamol Tablets Formulated using Sucrose and Formaldehyde Cross-Linked Starches

Modified‐release oral pellets for duodenum delivery of doxycycline hyclate

Oral Modified Release Multiple-Unit Particulate Systems: Compressed Pellets, Microparticles and Nanoparticles

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