Investigation into loss in ferrofluid magnetization

Li, J.; Gong, Xinglong; Lin, Yueqiang; Liu, X. D.; Chen, L. L.; Li, J. M.; Mao, Hong; Li, D. C.

doi:10.1063/1.4890866

Cited by 14 publications

(9 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The experimental results showed a decrease in magnetization (M) in the magnetic colloid suspensions as the carrier fluid viscosity increased. This finding is in agreement with previous research [20,23]. A magnetization value of dry SPIONs close to 65Am 2 /kg was reached beyond H=±8.0E 5 A/m at room temperature.…”

Section: Influence Of the Viscosity Of The Medium And Concentration Osupporting

confidence: 94%

“…When MNPs are captured and internalized by macrophages, they accumulate in intracellular organelles like lysosomes [18,29,[31][32][33][34], generating a decrease in the mechanical degrees of freedom in terms of MNP rotation and translation [15,26,35], which could affect their magnetic behavior. On the other hand, when MNPs are suspended in a viscous fluid, the viscosity of the medium and the nanoparticle concentration may generate a change in the magnetic moment relaxation processes of the MNPs [16,23,26,36]. Precise knowledge about the distribution, fate and spatial localization of MNPs within a biological environment is still challenging.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Influence of medium viscosity and intracellular environment on the magnetization of superparamagnetic nanoparticles in silk fibroin solutions and 3T3 mouse fibroblast cell cultures

et al. 2018

View full text Add to dashboard Cite

Biomedical applications based on the magnetic properties of superparamagnetic iron oxide nanoparticles (SPIONs) may be altered by the mechanical attachment or cellular uptake of these nanoparticles. When nanoparticles interact with living cells, they are captured and internalized into intracellular compartments. Consequently, the magnetic behavior of the nanoparticles is modified. In this paper, we investigated the change in the magnetic response of 14 nm magnetic nanoparticles (FeO) in different solutions, both as a stable liquid suspension (one of them mimicking the cellular cytoplasm) and when associated with cells. The field-dependent magnetization curves from inert fluids and cell cultures were determined by using an alternating gradient magnetometer, MicroMagTM 2900. The equipment was adapted to measure liquid samples because it was originally designed only for solids. In order to achieve this goal, custom sample holders were manufactured. Likewise, the nuclear magnetic relaxation dispersion profiles for the inert fluid were also measured by fast field cycling nuclear magnetic relaxation relaxometry. The results show that SPION magnetization in inert fluids was affected by the carrier liquid viscosity and the concentration. In cell cultures, the mechanical attachment or confinement of the SPIONs inside the cells accounted for the change in the dynamic magnetic behavior of the nanoparticles. Nevertheless, the magnetization value in the cell cultures was slightly lower than that of the fluid simulating the viscosity of cytoplasm, suggesting that magnetization loss was not only due to medium viscosity but also to a reduction in the mechanical degrees of freedom of SPIONs rotation and translation inside cells. The findings presented here provide information on the loss of magnetic properties when nanoparticles are suspended in viscous fluids or internalized in cells. This information could be exploited to improve biomedical applications based on magnetic properties such as magnetic hyperthermia, contrast agents and drug delivery.

show abstract

Section: Influence Of the Viscosity Of The Medium And Concentration Osupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Influence of medium viscosity and intracellular environment on the magnetization of superparamagnetic nanoparticles in silk fibroin solutions and 3T3 mouse fibroblast cell cultures

et al. 2018

View full text Add to dashboard Cite

show abstract

“…This value is lower than that one of the bulk magnetite or maghemite as it was previously observed for the MNPs of the observed average size due to nanoscaling effects [16,17]. At the same time magnetic measurements confirm well the concentration of the MNPs of ferrofluid previously defined by chemical titration technique [16,22]. Lower coercivity of the ferrofluid was observed.…”

Section: Resultssupporting

confidence: 61%

Magnetoimpedance Effect in CoFeMoSiB As-Quenched and Surface Modified Amorphous Ribbons in the Presence of Igon Oxide Nanoparticles of Water-Based Ferrofluid

et al. 2017

View full text Add to dashboard Cite

Giant magnetoimpedance (GMI) has been proposed as a powerful technique for biosensing. In GMI biosensors based on the magnetic label detection the change of the impedance of sensitive element under the application of an external magnetic field was analyzed in the presence of magnetic nanoparticles in a test solution. Amorphous ribbon-based GMI biodetectors have an advantage of low operation frequency and low cost. In this work, magnetic and GMI properties of amorphous Co 68.6 Fe 3.9 Mo 3.0 Si 12.0 B 12.5 ribbons were studied in as-quenched and surface modified states both without and in the presence of maghemite ferrofluid. After the surface modification the coercivity was slightly increased and saturation magnetization decreased in good agreement with increase of the surface roughness, a decrease of magnetic elements concentrations in the surface layer, and formation of a surface protective oxide layer. The GMI difference for as-quenched ribbons in absence and in the presence of ferrofluid was measurable for the frequency range of 2 to 10 MHz and the current intensities of 1 to 20 mA. Although the proposed surface modification by the ultrasound treatment did not improve the sensitivity limit for ferrofluid detection, it did not decrease it either.

show abstract

“…En la hipertermia magnética, la conversión de energía electromagnética en calor generado por SPIONs sometidas a campos magnéticos alternos (HAC) se puede utilizar para causar la muerte de células tumorales [42], [43]. Estudios recientes han demostrado que la respuesta magnética, y por lo tanto la eficiencia de calentamiento de SPIONs, se reduce significativamente cuando estas nanopartículas se colocan en líquidos portadores viscosos [44], [45] y dentro de células vivas o tejidos biológicos [46]- [53]. La mayor viscosidad del entorno biológico y la distribución espacial o la aglomeración de nanopartículas dentro de los orgánulos intracelulares influyen fuertemente en la eficacia de SPIONs para aumentar la temperatura del medio circundante [46], [47], [54], [55].…”

Section: Hipertermia Magnéticaunclassified

“…El hallazgo de la influencia de la viscosidad del medio y de la concentración sobre el magnetismo de SPIONs suspendidas en fluidos inertes, está de acuerdo con trabajos anteriores [44], [81]. Se consiguió valores de magnetización de SPIONs secos cercanos a 65Am 2 /kg más allá de H = ± 8.0E5 A / m a temperatura ambiente.…”

Section: Hipertermia Magnéticaunclassified

Contribución a las tecnologías hipertérmicas mediadas por nanopartículas para terapias anticancerígenas

Carvajal¹,

Simón²

View full text Add to dashboard Cite

of the thesis of Oscar Ernesto Simon Casanova Carvajal, presented as partial requirement to obtain the DOCTOR degree in BIOMEDICAL ENGINEERING.Madrid, June 28 th, 2017. CONTRIBUTION TO HYPOTHERMAL TECHNIQUES MEDIATED BY NANOPARTICLES FOR ANTICANCERIC THERAPIESAbstract:After the fusion of nanotechnology with medicine and bioengineering, fields of research in nanomedicine and nanobioengineering were created, which broadened the perspective of medical research and emerging new frontiers. These investigations have allowed new methods of approach to find solutions to long-standing human biological problems and the development and administration of therapeutic or pharmacological diagnoses. To achieve this, nanoparticles have been developed, which are miniaturized agents, which have given way to nanomedicine. The gold nanoparticles used in this study are nanorods (GNR) coated with G protein, a common receptor for mechanically anchoring antibodies. In this research hyperthermia plays a role of greatest importance which refers to the application of heat to destroy malignant cells by induction of apoptosis through the denaturation of proteins and the rupture of cell membranes. The application of gold nanoparticles generated by optical hyperthermia improve in-vitro therapy, and considerable advances were made in-vivo for animal models. In magnetic hyperthermia, the conversion of electromagnetic energy into heat generated by SPIONs subjected to alternating magnetic fields (HAC) can be used to cause the death of tumour cells. Recent studies have shown that the magnetic response, and therefore the heating efficiency of SPIONs, are significantly reduced when these nanoparticles are placed in viscous carrier liquids and within living cells or biological tissues. The higher viscosity of the biological environment and the spatial distribution or agglomeration of nanoparticles within the intracellular organelles strongly influence the efficacy of SPIONs to increase the temperature of the surrounding medium. These factors that arise from the nanobio-interaction make the heating efficiency in in-vivo applications less efficient and predictable than in ideal ferrofluids. Considerable advances were made in both techniques, in optical hyperthermia it was included until obtaining improvements in the introduction of dispersant material and biocompatible light such as Silica. The results suggested a considerable improvement in all the variables involved in the system such as irradiated power, time of exposure to the laser, concentration of gold nanoparticles (nanorods) and maintaining the mortality rate in cancer cells (CT2A) against cell lines considered healthy (MC3T3). In the case of magnetic hyperthermia, an electronic system was designed and built to generate excitatory waveforms different from conventional ones (sinusoidal), tolerance tests were carried out on the nanoparticles that will be used in the system. Also, it was demonstrated the existing physical phenomenon when the SPIONs are phagocytized by the cells, applying an intrace...

show abstract

Investigation into loss in ferrofluid magnetization

Cited by 14 publications

References 32 publications

Influence of medium viscosity and intracellular environment on the magnetization of superparamagnetic nanoparticles in silk fibroin solutions and 3T3 mouse fibroblast cell cultures

Influence of medium viscosity and intracellular environment on the magnetization of superparamagnetic nanoparticles in silk fibroin solutions and 3T3 mouse fibroblast cell cultures

Magnetoimpedance Effect in CoFeMoSiB As-Quenched and Surface Modified Amorphous Ribbons in the Presence of Igon Oxide Nanoparticles of Water-Based Ferrofluid

Contribución a las tecnologías hipertérmicas mediadas por nanopartículas para terapias anticancerígenas

Contact Info

Product

Resources

About