Investigation into the Effect of Humidity on Drug–Drug Interactions Using the Atomic Force Microscope

Young, Paul M.; Price, Robert; Tobyn, Mike; Buttrum, Mark; Dey, Fiona

doi:10.1002/jps.10250

Cited by 72 publications

(62 citation statements)

References 24 publications

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“…When compared directly, colloidal probe AFM proved to be superior to the tensile strength technique as the distribution of results was considerably narrower. A number of similar colloidal probe experiments carried out by other groups also confirmed the dominance of capillary forces between particles over electrostatic interactions at increasing levels of humidity (Berard et al, 2002a;Tsukada et al, 2004;Young et al, 2003). These experiments were carried out at different RH and with different API and carrier materials.…”

Section: Adhesion Measurementssupporting

confidence: 53%

Characterisation of dry powder inhaler formulations using atomic force microscopy

Weiss

McLoughlin

Cathcart

2015

International Journal of Pharmaceutics

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A B S T R A C TInhalation formulations are a popular way of treating the symptoms of respiratory diseases. The active pharmaceutical ingredient (API) is delivered directly to the site of action within the deep lung using an inhalation device such as the dry powder inhaler (DPI).The performance of the formulation and the efficiency of the treatment depend on a number of factors including the forces acting between the components. In DPI formulations these forces are dominated by interparticulate interactions. Research has shown that adhesive and cohesive forces depend on a number of particulate properties such as size, surface roughness, crystallinity, surface energetics and combinations of these. With traditional methods the impact of particulate properties on interparticulate forces could be evaluated by examining the bulk properties. Atomic force microscopy (AFM), however, enables the determination of local surface characteristics and the direct measurement of interparticulate forces using the colloidal probe technique. AFM is considered extremely useful for evaluating the surface topography of a substrate (an API or carrier particle) and even allows the identification of crystal faces, defects and polymorphs from high-resolution images. Additionally, information is given about local mechanical properties of the particles and changes in surface composition and energetics. The assessment of attractive forces between two bodies is possible by using colloidal probe AFM.This review article summarises the application of AFM in DPI formulations while specifically focussing on the colloidal probe technique and the evaluation of interparticulate forces.2015 Elsevier B.V. All rights reserved.

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Section: Adhesion Measurementssupporting

confidence: 53%

Characterisation of dry powder inhaler formulations using atomic force microscopy

Weiss

McLoughlin

Cathcart

2015

International Journal of Pharmaceutics

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“…57,58 The same phenomenon may also be seen in some devices if the patient by mistake exhales through the inhaler after the dose has been loaded.…”

Section: Dry Powder Inhalersmentioning

confidence: 78%

The ADMIT series — Issues in Inhalation Therapy. 5) Inhaler selection in children with asthma

Pedersen

Dubus

Crompton³

2010

Primary Care Respiratory Journal

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“…Due to the significant impact of meniscus forces on the flow behavior of powders, several studies have focused on the humidity dependence of adhesion for several commercially relevant powders like hydrated alumina, a silica aerogel, limestone, titania and zeolite [702] or pharmaceutical products like a-lactose monohydrate, salbutamol sulphate, budesonide, triamcinolone acetonide, and disodium cromoglycate [634,703,704]. Duong et al [705] used force-distance curves on 900-1100 mm glass beads that were exposed to different amount of water in a shaker.…”

Section: Meniscus Forcementioning

confidence: 99%

Force measurements with the atomic force microscope: Technique, interpretation and applications

Butt

Cappella

Kappl

2005

Surface Science Reports

3,246

2,949

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Investigation into the Effect of Humidity on Drug–Drug Interactions Using the Atomic Force Microscope

Cited by 72 publications

References 24 publications

Characterisation of dry powder inhaler formulations using atomic force microscopy

Characterisation of dry powder inhaler formulations using atomic force microscopy

The ADMIT series — Issues in Inhalation Therapy. 5) Inhaler selection in children with asthma

Force measurements with the atomic force microscope: Technique, interpretation and applications

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