Investigation into the in vivo mechanism of diosmetin in patients with breast cancer and COVID-19 using bioinformatics

Wang, Jin; Ma, Shengming; Long, Li; Chen, Yuhan; Yang, Qian; Wang, Feiyan; Zheng, Mei‐Ling; Miao, Song; Shi, Xiaopeng

doi:10.3389/fphar.2022.983821

Cited by 3 publications

(4 citation statements)

References 49 publications

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“…Over the past three decades, diosmetin has been shown to have a variety of therapeutic effects like anticancer activity on breast cancer as well as antioxidant, antibacterial, and anti-inflammatory activity. , The previous study demonstrated that diosmetin prevents the development of a tumor and suppresses angiogenesis in SC. The results of this study revealed that diosmetin blocks the migration of SC cells and also induces apoptosis via regulating caspase circuits …”

Section: Therapeutic Strategies For the Treatment Of Skin Cancermentioning

confidence: 73%

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A Comprehensive Review of Various Therapeutic Strategies for the Management of Skin Cancer

Dachani,

Kaleem,

Mujtaba

et al. 2024

ACS Omega

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Skin cancer (SC) poses a global threat to the healthcare system and is expected to increase significantly over the next two decades if not diagnosed at an early stage. Early diagnosis is crucial for successful treatment, as the disease becomes more challenging to cure as it progresses. However, identifying new drugs, achieving clinical success, and overcoming drug resistance remain significant challenges. To overcome these obstacles and provide effective treatment, it is crucial to understand the causes of skin cancer, how cells grow and divide, factors that affect cell growth, and how drug resistance occurs. In this review, we have explained various therapeutic approaches for SC treatment via ligands, targeted photosensitizers, natural and synthetic drugs for the treatment of SC, an epigenetic approach for management of melanoma, photodynamic therapy, and targeted therapy for BRAFmutated melanoma. This article also provides a detailed summary of the various natural drugs that are effective in managing melanoma and reducing the occurrence of skin cancer at early stages and focuses on the current status and future prospects of various therapies available for the management of skin cancer.

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Section: Therapeutic Strategies For the Treatment Of Skin Cancermentioning

confidence: 73%

“…The results of this study revealed that diosmetin blocks the migration of SC cells and also induces apoptosis via regulating caspase circuits. 125 7.5.4. Cantharidin (CTD).…”

Section: Therapeutic Strategies For the Treatmentmentioning

confidence: 99%

A Comprehensive Review of Various Therapeutic Strategies for the Management of Skin Cancer

Dachani,

Kaleem,

Mujtaba

et al. 2024

ACS Omega

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“…Early studies also reported that the severity of inflammation is proportion to the disease progression, and the inhibitor or antagonist of cytokines and inflammatory factors can effectively slow down the disease development. Bioinformatics analysis of COVID-19 in the early stage has helped us understand the specific mechanism of the disease (Taz et al 2021 ; Wang et al 2022 ). Ghanem had identified 17 different expressed proteins which showed a consistent change in other datasets and these genes were mainly enriched in inflammatory responses, platelet degranulation and neutrophil chemotaxis (Ghanem et al 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of Key Genes Related to Immune Cells in Patients with COVID-19 Via Integrated Bioinformatics-Based Analysis

2023

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COVID-19 has spread all over the world which poses a serious threat to social economic development and public health. Despite enormous progress has been made in the prevention and treatment of COVID-19, the specific mechanism and biomarker related to disease severity or prognosis have not been clarified yet. Our study intended to further explore the diagnostic markers of COVID-19 and their relationship with serum immunology by bioinformatics analysis. The datasets about COVID-19 were downloaded from the Gene Expression Omnibus (GEO) dataset. The differentially expressed genes (DEGs) were selected via the limma package. Then, weighted gene co-expression network analysis (WGCNA) was conducted to identify the critical module associated with the clinic status. The intersection DEGs were processed for further enrichment analysis. The final diagnostic genes for COVID-19 were selected and verified through special bioinformatics algorithms. There were significant DEGs between the normal and COVID-19 patients. These genes were mainly enriched in cell cycle, complement and coagulation cascade, extracellular matrix (ECM) receptor interaction, and the P53 signaling pathway. As much as 357 common intersected DEGs were selected in the end. These DEGs were enriched in organelle fission, mitotic cell cycle phase transition, DNA helicase activity, cell cycle, cellular senescence, and P53 signaling pathway. Our study also identified CDC25A, PDCD6, and YWAHE were potential diagnostic markers of COVID-19 with the AUC (area under curve), 0.958 (95% CI 0.920–0.988), 0.941(95% CI 0.892–0.980), and 0.929 (95% CI 0.880–0.971). Moreover, CDC25A, PDCD6, and YWAHE were correlated with plasma cells, macrophages M0, T cells CD4 memory resting, T cells CD8, dendritic cells, and NK cells. Our study discovered that CDC25A, PDCD6, and YWAHE can be used as diagnostic markers for COVID-19. Moreover, these biomarkers were also closely associated with immune cell infiltration, which plays a pivotal role in the diagnosis and progression of COVID-19. Supplementary Information The online version contains supplementary material available at 10.1007/s10528-023-10400-1.

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“…Recently, DIO has been reported to enhance immune cell infiltration and regulate the cellular microenvironment in patients with breast cancer. [ 16 ] As a result, we hypothesized that the antitumor effect of DIO might be related to its regulatory effect on the immune TME of GC. M2 phenotype macrophages are the most abundant immune cells in the TME.…”

Section: Introductionmentioning

confidence: 99%

Diosmetin inhibits the growth and invasion of gastric cancer by interfering with M2 phenotype macrophage polarization

Zhang

Luo

2023

J Biochem & Molecular Tox

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Overturning M2 phenotype macrophage polarization is a promising therapeutic strategy for gastric cancer (GC). Diosmetin (DIO) is a natural flavonoid with antitumor effect. The aim of this study was to investigate the effect of DIO on polarization of M2 phenotype macrophages in GC. THP‐1 cells were induced to M2 phenotype macrophages and co‐cultured with AGS cells. The effects of DIO were determined by flow cytometry, qRT‐PCR, CCK‐8, Transwell, and western blot. To explore the mechanisms, THP‐1 cells were transfected with adenoviral vectors containing tumor necrosis factor receptor‐associated factor 2 (TRAF2) or si‐TRAF2. DIO (0, 5, 10, and 20 μM) restrained the M2 phenotype macrophage polarization. In addition, DIO (20 μM) reversed the increased viability and invasion of AGS cells induced by the co‐culture of M2 macrophages. Mechanistically, TRAF2 knockdown inhibited the effect of M2 phenotype macrophages on AGS cells' growth and invasion. Furthermore, DIO (20 μM) was found to decrease TRAF2/NF‐κB activity in GC cells. However, TRAF2 overexpressed reversed the inhibitory effect of DIO on the co‐culture system. The in vivo study confirmed that DIO treatment (50 mg/kg) could repress the growth of GC. DIO treatment markedly reduced the expressions of Ki‐67 and N‐cadherin, and decreased the protein levels of TRAF2 and p‐NF‐κB/NF‐κB. In conclusion, DIO inhibited the growth and invasion of GC cells by interfering with M2 phenotype macrophage polarization through repression of the TRAF2/NF‐κB signaling pathway.

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Investigation into the in vivo mechanism of diosmetin in patients with breast cancer and COVID-19 using bioinformatics

Cited by 3 publications

References 49 publications

A Comprehensive Review of Various Therapeutic Strategies for the Management of Skin Cancer

A Comprehensive Review of Various Therapeutic Strategies for the Management of Skin Cancer

Identification of Key Genes Related to Immune Cells in Patients with COVID-19 Via Integrated Bioinformatics-Based Analysis

Diosmetin inhibits the growth and invasion of gastric cancer by interfering with M2 phenotype macrophage polarization

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