Investigation of 1,2-Dimyristoyl-sn-Glycero-3-Phosphoglycerol-Sodium (DMPG-Na) Lipid with Various Metal Cations in Nanocochleate Preformulation: Application for Andrographolide Oral Delivery in Cancer Therapy

Ahiwale, Raj J.; Bothiraja, C.; Pawar, Atmaram

doi:10.1208/s12249-020-01801-1

Cited by 19 publications

(7 citation statements)

References 62 publications

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“…Furthermore, ANDNCs showed minimum accumulation within the vital organs like the kidney, liver, and spleen. 65 These new delivery devices for andrographolide greatly enhance the efficiency of andrographolide in treating various diseases.…”

Section: New Delivery Systems For Andrographolidementioning

confidence: 99%

Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective

Liu

You

et al. 2021

Medicinal Research Reviews

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Andrographolide, a well-known natural lactone having a range of pharmacological actions in traditional Chinese medicine. It has long been used to cure a variety of ailments. In this review, we cover the pharmacokinetics and pharmacological activity of andrographolide which supports its further clinical application in cancers and inflammatory diseases. Growing evidence shows a good therapeutic effect in inflammatory diseases, including liver diseases, joint diseases, respiratory system diseases, nervous system diseases, heart diseases, inflammatory bowel diseases, and inflammatory skin diseases. As a result, the effects of andrographolide on immune cells and the processes that underpin them are discussed. The preclinical use of andrographolide to different organs in response to malignancies such as colorectal, liver, gastric,

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Section: New Delivery Systems For Andrographolidementioning

confidence: 99%

Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective

Liu

You

et al. 2021

Medicinal Research Reviews

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“…Further, AGLloaded solid lipid nanoparticles inhibited head and neck cancer [43]. Andrographolide-loaded nanocochleates were assessed for their physiochemical properties to be used as an oral delivery alternative for clinical trials in cancer therapy [44]. In addition, AGL nanoparticles were also tested and established to protect against cigarette smoking-induced chronic obstructive pulmonary disease [45].…”

Section: Functional Prospective Of Andrographolide (Agl) On Human Healthmentioning

confidence: 99%

Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health

et al. 2021

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Plants consistently synthesize and accumulate medically valuable secondary metabolites which can be isolated and clinically tested under in vitro conditions. An advancement with such important phytochemical production has been recognized and utilized as herbal drugs. Bioactive andrographolide (AGL; C20H30O5) isolated from Andrographis paniculate (AP) (Kalmegh) is a diterpenoid lactones having multifunctional medicinal properties including anti-manic, anti-inflammatory, liver, and lung protective. AGL is known for its immunostimulant activity against a variety of microbial infections thereby, regulating classical and alternative macrophage activation, Ag-specific antibody production during immune disorder therapy. In vitro studies with AGL found it to be effective against multiple tumors, neuronal disorders, diabetes, pneumonia, fibrosis, and other diverse therapeutic misadventures. Generally, virus-based diseases like ZIKA, influenza A virus subtype (H1NI), Ebola (EBOV), Dengue (DENV), and coronavirus (COVID-19) epidemics have greatly increased scientific interest and demands to develop more effective and economical immunomodulating drugs with minimal side effects. Trials and in vitro pharmacological studies with AGL and medicinally beneficial herbs might contribute to benefit the human population without using chemical-based synthetic drugs. In this review, we have discussed the possible role of AGL as a promising herbal-chemo remedy during human diseases, viral infections and as an immunity booster.

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“…They may aggregate; hence addition of aggregation inhibitor is required [ 7 ]. Numerous studies have been carried out on the formulation and evaluation of nanocochleates of various anticancer agents like fisetin [ 8 ], paclitaxel [ 9 , 10 ], raloxifene [ 11 ], quercetin [ 12 ], erlotinib, and dexketoprofen [ 13 ], doxorubicin with folic acid [ 14 ], docetaxel [ 15 ], curcumin [ 16 ], hydrocamptothecin [ 17 ], cytarabine [ 18 , 19 ], and imatinib with dexketoprofen [ 20 ] and demonstrated to improve the efficacy for the treatment of various types of cancers.…”

Section: Introductionmentioning

confidence: 99%

Curcumin and quercetin loaded nanocochleates gel formulation for localized application in breast cancer therapy

Tilawat,

Bonde

2023

Heliyon

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Investigation of 1,2-Dimyristoyl-sn-Glycero-3-Phosphoglycerol-Sodium (DMPG-Na) Lipid with Various Metal Cations in Nanocochleate Preformulation: Application for Andrographolide Oral Delivery in Cancer Therapy

Cited by 19 publications

References 62 publications

Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective

Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective

Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health

Curcumin and quercetin loaded nanocochleates gel formulation for localized application in breast cancer therapy

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