Investigation of acidic pharmaceuticals in river water and sediment by microwave-assisted extraction and gas chromatography–mass spectrometry

Varga, Margit; Dobor, József; Helenkár, A.; Jurecska, Laura; Yao, Jun; Záray, Gyula

doi:10.1016/j.microc.2010.02.010

Cited by 69 publications

(18 citation statements)

References 29 publications

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“…For example, E1 and DES were not detected in all investigated samples, on the other hand, the concentrations of E2 and E3 in soils were higher in comparison to the presented literature data. The concentration of diclofenac in sediment from fish ponds (Bolszewo) was in the range presented for natural sediments collected along the Danube river at Budapest (Hungary) (Varga et al, 2010).…”

Section: Application Of the Developed Methods For Determining Nsaids Amentioning

confidence: 63%

“…In activated and digested sewage sludge (Germany), the concentrations of E1, E2 and EE2, were 37, 49 and 17 ng/g, respectively (Ternes et al, 2002). The levels of the non-steroidal antiinflammatories diclofenac and naproxen determined by Varga et al (2010) in natural sediments were 2-38 ng/g, established for NSAIDs in soil, sediment and sludge samples collected from Andalusia in the range ng/kg (Azzouz and Ballesteros, 2012).…”

Section: Application Of the Developed Methods For Determining Nsaids Amentioning

confidence: 97%

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Simultaneous determination of non-steroidal anti-inflammatory drugs and oestrogenic hormones in environmental solid samples

Kumirska

Migowska

Caban

et al. 2015

Science of The Total Environment

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Section: Application Of the Developed Methods For Determining Nsaids Amentioning

confidence: 63%

Section: Application Of the Developed Methods For Determining Nsaids Amentioning

confidence: 97%

Simultaneous determination of non-steroidal anti-inflammatory drugs and oestrogenic hormones in environmental solid samples

Kumirska

Migowska

Caban

et al. 2015

Science of The Total Environment

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“…19 For the analysis of pharmaceuticals in environmental solids, sample pre-treatment steps typically include extraction and analyte enrichment and clean-up, as these processes are essential and provide the opportunity to quantify many pharmaceutical compounds down to ng L -1 or ng Kg -1 concentrations. 20,21 A variety of extraction procedures has been reported for organic pollutants, including pharmaceuticals, from solid environmental matrices such as sediment including methods based on microwave assisted extraction (MAE) 18,22 and pressurized liquid extraction (PLE -which is also commonly known as accelerated solvent extraction (ASE)). 19 For example, the use of ASE for extraction of pharmaceuticals from sediment results in recoveries greater than 116%.…”

Section: 18mentioning

confidence: 99%

Determination of pharmaceuticals in freshwater sediments using ultrasonic-assisted extraction with SPE clean-up and HPLC-DAD or LC-ESI-MS/MS detection

Al-Khazrajy

Boxall

2017

Anal. Methods

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A robust and sensitive analytical method is presented for the extraction and determination of six pharmaceuticals in freshwater sediments. The pharmaceuticals were extracted from sediment using ultrasonic extraction with 2% NH 4 OH in methanol (MeOH), followed by extraction into 2% formic acid in MeOH and then MeOH only. The resulting extracts were then analysed, after clean-up on HLB solid phase extraction cartridges, using a single gradient run using a Zorbax Eclipse XDB-C18 (150 × 4.6 mm, 5 m) column and a mobile phase consisting of 10 mM ammonium acetate and MeOH (pH=4.8). Analytes were detected and quantified using either Diode Array Detector (DAD) or tandem mass spectrometry (MS/MS) with electrospray ionization in positive mode. Validation studies were carried out using ten sediments sampled from the UK and Iraq with a wide range of characteristics. The mean calculated recoveries for fortified samples in all studied sediments ranged from 74.5 to 114.6% for atenolol, 72.3 to 124.9% for amitriptyline, 76.5 to 105% for mefenamic acid and 70.1 to 102% for diltiazem. Cimetidine and ranitidine showed lower recoveries which ranged from 40.2 to 68.4% and 30.4 to 55.2% respectively. Relative standard deviations (RSD) of recoveries for all sediment-pharmaceutical combinations ranged from 1.6 to 15.8%. The detection limits in sediments for the six analytes ranged from 15 to 58.5 ng g -1 and 0.03 to 3.5 ng g

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“…Ra et al 2008 There are limited data on pharmaceutical sediment sorption, accumulation, and formation of transformation products (Bu et al 2013;Savci 2013) (Table 4). One study reported concentrations 10 -32 times higher in sediments than in water (Agunbiade and Moodley 2015) with other studies confirming the importance of sediments as sorbents (Stein et al 2008;Yamamoto et al 2009;Varga et al 2010;Martínez-Hernández et al 2014;Svahn and Bjorklund 2015;Li et al 2015). For acidic pharmaceuticals, however, the charge repulsion limits pharmaceutical -sediment interactions (Koumaki et al 2016).…”

Section: Partitioning To Suspended Solids and Sedimentsmentioning

confidence: 90%

Processes of distribution of pharmaceuticals in surface freshwaters: implications for risk assessment

et al. 2018

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The global consumption and production of pharmaceuticals is increasing concomitantly with concern regarding their environmental fate and effects. Active pharmaceutical ingredients are mainly released into the aquatic environment through wastewater effluent discharge. Once in the environment, pharmaceuticals can undergo processes of natural attenuation, i.e. dilution, sorption, transformation, depending on physico-chemical properties of the compound, such as water solubility, lipophilicity, vapour pressure, and environmental conditions, such as pH, temperature and ionic strength. A major natural attenuation process is the sorption on dissolved organic matter, colloids, suspended solids and sediments, which in turn control pharmaceuticals distribution, residence time and persistence in aquatic systems. Here we review studies of sorption capacity of natural sorbents to pharmaceuticals. These report on the importance of several environmental and sorbent-specific properties, such as the composition, quality, and amount of the sorbent, and the environmental pH, which determines the speciation of both the sorbent and compound. The importance of accounting for distribution processes on freshwater sorbents for any determination of environmental concentrations of pharmaceuticals is apparent, while the reliability of surrogate standards for measuring dissolved organic matter (DOM) distribution is evaluated in the context of the need for robust environmental risk assessment protocols.

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Investigation of acidic pharmaceuticals in river water and sediment by microwave-assisted extraction and gas chromatography–mass spectrometry

Cited by 69 publications

References 29 publications

Simultaneous determination of non-steroidal anti-inflammatory drugs and oestrogenic hormones in environmental solid samples

Simultaneous determination of non-steroidal anti-inflammatory drugs and oestrogenic hormones in environmental solid samples

Determination of pharmaceuticals in freshwater sediments using ultrasonic-assisted extraction with SPE clean-up and HPLC-DAD or LC-ESI-MS/MS detection

Processes of distribution of pharmaceuticals in surface freshwaters: implications for risk assessment

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