Investigation of ADAMTS-1, BAX and IL-10 Expressions in Granulosa Cells Determinanting Fertilization Success in IVF

Çavuş, Yunus; Deger, Ugur

doi:10.4067/s0717-95022020000200427

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…IL10 is an anti-inflammatory cytokine that is involved in apoptosis (Dhingra et al, 2009), and in this study, we found that it was a donkey specific up-DEG (Figure 4C). It has been reported in the literature that the expression of IL10 in granulosa cells is related to the success rate of IVF (Çavus and Deger, 2020). Moreover, the expression of IL10 attenuates the apoptosis rate of cells (Dhingra et al, 2009).…”

Section: Discussionmentioning

confidence: 96%

Comparative Transcriptomics Uncover the Uniqueness of Oocyte Development in the Donkey

Zhang

Sun

et al. 2022

Front. Genet.

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The donkey is an important domestic animal, however the number of donkeys world-wide is currently declining. It is therefore important to protect their genetic resources and to elaborate the regulatory mechanisms of donkey reproduction, particularly, oocyte development. Here, we adopted comparative transcriptomic analysis and weighted gene co-expression network analysis (WGCNA) to uncover the uniqueness of donkey oocyte development compared to cattle, sheep, pigs, and mice, during the period from germinal vesicle (GV) to metaphase II (MII). Significantly, we selected 36 hub genes related to donkey oocyte development, including wee1-like protein kinase 2 (WEE2). Gene Ontology (GO) analysis suggested that these genes are involved in the negative regulation of cell development. Interestingly, we found that donkey specific differentially expressed genes (DEGs) were involved in RNA metabolism and apoptosis. Moreover, the results of WGCNA showed species-specific gene expression patterns. We conclude that, compared to other species, donkey oocytes express a large number of genes related to RNA metabolism to maintain normal oocyte development during the period from GV to MII.

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Section: Discussionmentioning

confidence: 96%

Comparative Transcriptomics Uncover the Uniqueness of Oocyte Development in the Donkey

Zhang

Sun

et al. 2022

Front. Genet.

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Anti-Müllerian hormone (ovarian reserve) in rheumatoid arthritis patients: correlation with disease activity

Israel,

Saleh,

Ahmed

et al. 2024

Egypt Rheumatol Rehabil

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Background Rheumatoid arthritis is considered one of the most common chronic inflammatory autoimmune diseases that lead to affection of several joints, as well as extra-articular organ involvement. Rheumatoid arthritis women tend to menopause somewhat earlier. This was attributed to primary ovarian insufficiency because of autoimmune disorders. Anti-Müllerian hormone is a marker used for evaluating preantral follicle reserve. It provides a very sensitive way to reflect the ovarian reserve and has become a crucial factor in determining it. The study aimed to show the influence of rheumatoid arthritis and its activity on ovarian reserve assessed using anti-Müllerian hormone serum levels. Results Our cross-sectional study involved 30 rheumatoid arthritis female patients with an age range between 25 and 35 years. The Disease Activity Score (DAS 28-ESR) was used to assess the degree of disease activity. Serum level of anti-Müllerian hormone was determined using quantitative enzyme-linked immunosorbent assay and the correlation with the disease activity as well as with the medications the patients were receiving was analyzed. A statistically significant relation was found amid the disease activity and the anti-Müllerian hormone level. Serum levels of anti-Müllerian hormone were found less in cases with high disease activity than in low to moderate cases. Different medications had no effect on anti-Müllerian hormone levels. Conclusions Rheumatoid arthritis high disease activity was linked to a diminished level of serum anti-Müllerian hormone.

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Investigation of ADAMTS-1, BAX and IL-10 Expressions in Granulosa Cells Determinanting Fertilization Success in IVF

Cited by 2 publications

References 35 publications

Comparative Transcriptomics Uncover the Uniqueness of Oocyte Development in the Donkey

Comparative Transcriptomics Uncover the Uniqueness of Oocyte Development in the Donkey

Anti-Müllerian hormone (ovarian reserve) in rheumatoid arthritis patients: correlation with disease activity

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