2023
DOI: 10.1101/2023.02.09.527821
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Investigation of adenosine A1 receptor mediated β-arrestin 2 recruitment using a split-luciferase assay

Abstract: Background: Adenosine A1 receptor (A1AR) plays a prominent role in neurological and cardiac diseases as well as during inflammatory processes. Its endogenous ligand adenosine is known to be one of the key players in the sleep-wake cycle. Like other G protein-coupled receptors, stimulation of A1AR leads to the recruitment of arrestins in addition to the activation of G proteins. So far, little is known about the role of these proteins for signal transduction and regulation of A1AR compared to the activation of … Show more

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