This work primarily investigates the performance and structural integrity of the Wells turbines for power production in coastal locations and their associated unmanned vehicles. An innovative design procedure is imposed on the design stage of the Wells turbine and thus so seven different models are generated. In the first comprehensive investigation, these seven models underwent computational hydrodynamic analysis using ANSYS Fluent 17.2 for various coastal working environments such as hydro-fluid speeds of 0.34 m/s, 1.54 m/s, 12 m/s, and 23 m/s. After this primary investigation, the best-performing Wells turbine model has been imposed as the second comprehensive computational investigation for three unique design profiles. The imposed unique design profile is capable of enhancing the hydro-power by 15.19%. Two detailed, comprehensive investigations suggest the best Wells turbine for coastal location-based applications. Since the working environments are complicated, additional advanced computational investigations are also implemented on the best Wells turbine. The structural withstanding capability of this best Wells turbine model has been tested through coupled computational hydro-structural analysis for various lightweight materials. This best Wells turbine also enforces the vibrational failure factors such as modal and harmonic vibrational analyses. Finally, advanced and validated coupled engineering approaches are proposed as good methodology for coastal location-based hydropower applications.