Persistent organic pollutants (POPs) represent a significant environmental problem due to their toxicity, with a high capacity to persist in the environment, resistance to conventional degradation methods, the ability to accumulate in living organisms and their magnification in food chains or food. In this review article, the impacts on health and environmental components are examined. Strategies and measures for control, mitigation and/or minimization of POPs are also addressed. Agricultural and industrial activities, inadequate final disposal of solid waste and lack of wastewater treatment are identified as the main sources of POP emissions. In addition, innovative and promising technologies are analyzed, such as nanotechnology, bioremediation, rhizoremediation, biochar, chromatography techniques, ultrasound, among others, for the adequate treatment of POPs. The review highlights both the advantages and limitations of these technologies, pointing out areas that still require developments to achieve effective treatments. More economical and ecological alternatives are also mentioned to counteract the impacts of POPs.