Investigation of an outbreak of multidrug-resistant Acinetobacter baumannii in trauma intensive care unit

Channel Formation by CarO, the Carbapenem Resistance-Associated Outer Membrane Protein of Acinetobacter baumannii

“…This opportunistic pathogen causes a variety of hospital-acquired infections, including pneumonia, urinary tract infections, bacteremia, and meningitis, especially in immunocompromised patients (for a review, see reference 6). Hospital outbreaks due to multidrug-resistant (MDR) A. baumannii strains have become increasingly common in hospitals worldwide and especially in intensive care units (17,18,51) and burn units (6,10,37,52,56,58). These multidrug-resistant strains are frequently resistant to the usual drug families such as aminoglycosides, fluoroquinolones, and ␤-lactams (penicillins and cephalosporins), although carbapenems remain the most used antimicrobial drugs.…”

Successful control of outbreak caused by clonally related extensively-resistant Acinetobacter baumannii in an intensive care unit

“…Environmental contamination has been responsible for spread of pan-resistant A. baumannii strains in ICUs; hands being the most important source for transmittance [14]. Another associated problem with Acinetobacter species is persistence on inanimate objects thus facilitating colonization and spread [15].…”

Hygienemaßnahmen bei Infektionen oder Besiedlung mit multiresistenten gramnegativen Stäbchen

“…baumannii gilt als Ausnahme unter den gramnegativen Stäbchen mit einer ausgesprochen hohen Umweltresistenz [284,313]. In einer Reihe von Ausbrü-chen wurden entsprechende Reservoire in der unbelebten Umgebung als Quelle identifiziert [118,[314][315][316][317][318][319][320][321][322][323]. Neben der Umwelt wurden Reservoire in medizinischen Geräten [324][325][326] March et al [160] berichteten über die Nachweishäufigkeit von ESBL-Bildnern (allgemein) bei insgesamt 225 Personen (Heimbewohner, Mitarbeitern und geriatrische Patienten).…”