Investigation of anaemia

Thomas, Angela

doi:10.1016/j.cupe.2004.10.007

Cited by 6 publications

(4 citation statements)

References 2 publications

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“…W omawianym przypadku wykluczono krwawienie i hemolizę przebiegające ze zwiększoną liczbą retykulocytów. Retykulocytopenia w opisanym przypadku wskazywała na zahamowanie erytropoezy w postaci aplazji/hipoplazji szpiku wrodzonej lub wtórnej do naciekania szpiku przez komórki nowotworowe [11]. Mielogram potwierdził stłumie-nie układu erytroblastycznego, jednocześnie wykryto replikację parwowirusa B19.…”

Section: Opis Przypadkuunclassified

Niedokrwistość Blackfana i Diamonda z towarzyszącą replikacją parwowirusa B19. Opis przypadku

Krukowska-Jaros¹,

Niedzielska²,

Ussowicz³

et al. 2015

Pediatria Polska

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p e d i a t r i a p o l s k a 9 0 ( 2 0 1 5 ) 2 5 1 -2 5 5 i n f o r m a c j e o a r t y k u l e Historia artykułu: Otrzymano: 02.02.2015 Zaakceptowano: 27.03.2015 Dostępne online: 08.04.2015 Słowa kluczowe: niemowlę anemia niedokrwistości wrodzone cechy dysmorficzne Keywords: Infant Anaemia Congenital anaemia Dysmorphic features a b s t r a c t Anaemia is one of the most common haematological problems in infants. Diagnosis of anaemia is based on anamnesis, the results of physical examination and basic laboratorytests. During infancy, one of the main causes of anaemia is iron deficiency but in some cases haematopoiesis can be hampered by myeloproliferative disease, congenital or acquired bone marrow failure, too. This paper presents a case report of a 6-month-old girl with typical dysmorphic features. Initially the girl was diagnosed with iron-deficiency anaemia, due to suspected chronic gastrointestinal bleeding, as a result of cow's milk protein allergy. A replication of Parvovirus B19 was found in peripheral blood and bone marrow. After therapy with iron supplementation, milk-free diet and intravenous immunoglobulins, her haematological parameters have not improved and the girl required multiple packed red blood cell transfusions. After additional testing, the patient was diagnosed with Diamond-Blackfan anaemia, and was treated with prednisone, which led to improvement and transfusion independence. This case illustrates the need for accurate diagnosis even in common paediatric ailments.

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Section: Opis Przypadkuunclassified

Niedokrwistość Blackfana i Diamonda z towarzyszącą replikacją parwowirusa B19. Opis przypadku

Krukowska-Jaros¹,

Niedzielska²,

Ussowicz³

et al. 2015

Pediatria Polska

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“…As a baseline, initial laboratory work-up when investigating anaemia should include full blood count (including red cell indices), reticulocyte count and peripheral blood film [54][55][56]. Arguably, reticulocyte count is the single most important laboratory investigation in any case of anaemia.…”

Section: Fig 1 Aetiologic Classification Of Anaemiamentioning

confidence: 99%

“…Coombs test are useful in investigating immune related causes such as auto-immune anaemias and haemolytic transfusion reactions [67]. Haemoglobin electrophoresis and HPLC are highly informative in diagnosis or exclusion of abnormal haemoglobin variants such as sickle cell disease and thalassemia [56,68,69]. G6PD assay should be requested in suspected cases of haemolytic anaemia especially in males.…”

Section: Fig 1 Aetiologic Classification Of Anaemiamentioning

confidence: 99%

Approach to Anaemia Diagnosis in Developing Countries: Focus on Aetiology and Laboratory Work-Up

Ademola

2015

IBRR

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Introduction: Anaemia is a significant public health problem in developing countries. Anaemia is never normal. The etiology of the anaemia should always be sought. Diagnosis of its cause and early treatment is crucial to improving the quality of life among affected persons. There is a need to provide practicing physicians with a good theoretical framework and a practical algorithm for arriving accurately at anaemia diagnosis. Objective: This article seeks to collect, collate and concisely review anaemias with emphasis on the prevalent aetiologies and laboratory diagnosis in developing countries Results: The etiology of anaemia in developing countries is myriad and requires accurate diagnosis. Nutritional (substrate) deficiencies and chronic diseases account for a significant proportion of acquired anaemias.The predominating inherited causes include haemoglobinopathies, red cell enzymopathies and membranopathies. A systematic approach will help the physician paddle through the large list of differentials, to cone down on precise diagnosis. Relevant clinical history, physical examination and baseline investigations are imperative. Further

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“…Once a blood transfusion has been given, further evaluation for the cause of anaemia may become more diffi cult. While general approaches to the diagnostic evaluation of anaemic children can be found in standard textbooks or review articles, 1,2 strategies in resolving diagnostic mysteries concerning children with severe anaemia who are already on blood transfusion treatment are lacking. The Children's Haematology and Cancer Centre of Mount Elizabeth Hospital in Singapore has been receiving international patients for diagnostic and therapeutic purposes.…”

Section: Introductionmentioning

confidence: 99%

Transfusion-Dependent Anaemia of Undetermined Origin: A Distinctive Syndrome in Paediatric Medical Tourism

Lee

2012

Ann Acad Med Singap

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Introduction: The underlying diagnosis of severe anaemic illnesses in children may not be easy to identify at times, especially when regular blood transfusion has been started. Materials and Methods: International children patients attending a haematology clinic for diagnostic evaluation were identified retrospectively if they had to receive repeated blood transfusions with an undiagnosed illness or an incorrect diagnosis. Their demographic data, presenting features, and eventual diagnosis were described. Results: Twelve children including 7 boys were enrolled from March 2007 to August 2011. Five came from Vietnam; 2 each came from Bangladesh and Indonesia; and 1 each from Hong Kong, Myanmar, and Ukraine. Their illnesses started at a mean age of 1.5 years (0.1 to 6.6) and they had been receiving blood transfusion for a mean duration of 2.5 years (0.1 to 9.9) years prior to the evaluation. Thalassemia major was the first diagnosis in 5 cases; one had been treated for autoimmune haemolytic anaemia while the rest had not been given a diagnosis. After the evaluation, 4 children were diagnosed with Diamond Blackfan anaemia, 3 were diagnosed with hereditary spherocytosis, and one each with hereditary pyropoikilocytosis, congenital sideroblastic anaemia, congenital thrombotic thrombocytopenic purpura, transient erythroblastopenia of childhood, and autoimmune myelofibrosis associated with human immunodeficiency virus infection. Conclusion: A definitive diagnosis can be identified in this cohort of children on medical tourism with severe anaemic illnesses requiring repeated transfusions with diagnostic approaches that circumvent the interference of transfused cells. Key words: Child health services, Diagnostic errors, Diamond Blackfan anaemia, Hereditary spherocytosis

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Investigation of anaemia

Cited by 6 publications

References 2 publications

Niedokrwistość Blackfana i Diamonda z towarzyszącą replikacją parwowirusa B19. Opis przypadku

Niedokrwistość Blackfana i Diamonda z towarzyszącą replikacją parwowirusa B19. Opis przypadku

Approach to Anaemia Diagnosis in Developing Countries: Focus on Aetiology and Laboratory Work-Up

Transfusion-Dependent Anaemia of Undetermined Origin: A Distinctive Syndrome in Paediatric Medical Tourism

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