Investigation of Anti-Corrosive Performance of a Si-Doped DLC-Coated Magnesium Alloy Stent Deposited by RF-Plasma CVD

Nakatani, Tatsuyuki; Takeuchi, Harumichi; Wada, Akira; Yamashita, Shuzo

doi:10.2494/photopolymer.32.511

Cited by 12 publications

(3 citation statements)

References 32 publications

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“…Recent simulation studies regarding the corrosion of the materials in the literature are conducted with Mg-based biodegradable stents such as AZ31 or WE43. [54,76,77] However, there is no such study that analyzes stents in terms of their corrosion behavior by combining it with the potential ISR risk. Electrochemical analysis of the stent surface with the CAD models is presented in this study.…”

Section: Discussionmentioning

confidence: 99%

Computer‐Aided Analysis of the Corrosion Inhibition by Carbon‐Based Thin‐Film Coating on Vascular Bare Metal Stent Models

Akdoğan

Istanbullu

2022

Advcd Theory and Sims

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A simulation study of inhibiting the corrosion and corrosion-based restenosis is presented by diamond-like carbon (DLC) thin-film coating on bare-metallic intravascular stent models. The stents are designed and placed in a blood vessel model including a fatty-plaque layer in the study. 316L-stainless steel, CoCr-alloy, and nitinol are assigned to the stent models considering stent manufacturing. Modeled stents are coated with a carbon-based structure that mimics the DLC thin film. The electrochemical simulations are performed under the dynamic non-Newtonian blood flow condition for a 1 year period. Electrolytic current densities, corrosion, and restenosis rates of the bare and coated stents are simulated using time-dependent laminar flow and corrosion modules in multiphysics analysis software. Among the bare-stent models, the highest corrosion rate is observed for 316L with 79 µm year −1 and the minimum corrosion rate is observed for nitinol with 9 µm year −1 . Restenosis rates increase up to 36 µm year −1 due to the charged-particle adhesion on the bare stent surfaces. However, DLC-thin-film coating reduces corrosion and in-stent restenosis (ISR) rates down to 0.94 and 0.2 µm year −1 respectively. It can be concluded that surface passivation by thin-film DLC coating may be considered a promising candidate for novel stent designs having lower corrosion-based issues and ISR risks.

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Section: Discussionmentioning

confidence: 99%

Computer‐Aided Analysis of the Corrosion Inhibition by Carbon‐Based Thin‐Film Coating on Vascular Bare Metal Stent Models

Akdoğan

Istanbullu

2022

Advcd Theory and Sims

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“…Biocompatible and drug-delivery polymers may be synthesized as thin films on micro- and nanostructured surfaces. Moreover, the coatings can be applied at room temperature so that temperature-sensitive therapeutic drugs can be encapsulated with a polymer film without thermal degradation …”

Section: Surface-deposition Techniquesmentioning

confidence: 99%

Drug-Eluting, Bioresorbable Cardiovascular Stents─Challenges and Perspectives

Vallejo-Zamora

Vega-Cantú

Rodrı́guez

et al. 2022

ACS Appl. Bio Mater.

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Globally, the leading causes of natural death are attributed to coronary heart disease and type 1 and type 2 diabetes. High blood pressure levels, high cholesterol levels, smoking, and poor eating habits lead to the agglomeration of plaque in the arteries, reducing the blood flow. The implantation of devices used to unclog vessels, known as stents, sometimes results in a lack of irrigation due to the excessive proliferation of endothelial tissue within the blood vessels and is known as restenosis. The use of drug-eluting stents (DESs) to deliver antiproliferative drugs has led to the development of different encapsulation techniques. However, due to the potency of the drugs used in the initial stent designs, a chronic inflammatory reaction of the arterial wall known as thrombosis can cause a myocardial infarction (MI). One of the most promising drugs to reduce this risk is everolimus, which can be encapsulated in lipid systems for controlled release directly into the artery. This review aims to discuss the current status of stent design, fabrication, and functionalization. Variables such as the mechanical properties, metals and their alloys, drug encapsulation and controlled elution, and stent degradation are also addressed. Additionally, this review covers the use of polymeric surface coatings on stents and the recent advances in layer-by-layer coating and drug delivery. The advances in nanoencapsulation techniques such as liposomes and micro- and nanoemulsions and their functionalization in bioresorbable, drug-eluting stents are also highlighted.

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“…Coatings based on diamond-like carbon (DLC) are also among recently-developed coatings for the protection of Mg alloys owing to their chemical inertness, low friction, and high hardness [20]. An interlayer metallic film such as Si or Cr is usually used between the substrate and DLC film for the enhancement of coating adhesion [21,22]. In this article, new coating materials for the protection of magnesium and its alloys including rare earth conversion coatings, hybrid coatings, DLC coating, and composite polymeric coatings, have been discussed and recent advancements in these fields have been reviewed.…”

Section: Abstract a R T I C L E I N F O R M A T I O Nmentioning

confidence: 99%

Recent progress in materials used towards corrosion protection of Mg and its alloys

Ghazanfari

Hasanizadeh

Eskandarinezhad

et al. 2020

jcc

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Investigation of Anti-Corrosive Performance of a Si-Doped DLC-Coated Magnesium Alloy Stent Deposited by RF-Plasma CVD

Cited by 12 publications

References 32 publications

Computer‐Aided Analysis of the Corrosion Inhibition by Carbon‐Based Thin‐Film Coating on Vascular Bare Metal Stent Models

Computer‐Aided Analysis of the Corrosion Inhibition by Carbon‐Based Thin‐Film Coating on Vascular Bare Metal Stent Models

Drug-Eluting, Bioresorbable Cardiovascular Stents─Challenges and Perspectives

Recent progress in materials used towards corrosion protection of Mg and its alloys

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